摘要
目的观察常规血液透析与血液灌流对终末期肾脏疾病（end stage renal disease，ESRD）患者微炎症状态的影响。方法选择我院2012年1月至2013年10月就诊的68例ESRD患者作为研究对象，回顾性分析病例资料，按照治疗方案分为2组，常规血液透析治疗的32例作为对照组，血液灌流治疗的36例作为观察组，观察比较2组患者治疗前后的肾功能、微炎症状态以及生活质量的改善情况。结果治疗前2组患者的肾小球滤过率（glomerular filtration rate，GFR）、血尿素氮（BUN）及血肌酐（SCr）比较差异均无统计学意义（P〉0．05），治疗后3个月2组患者的GFR、BUN及SCr均明显改善（PG0．05），但组间差异无统计学意义（P〉0．05）；治疗前2组患者的超敏C反应蛋白（hypersensitive C-reactive protein，hs-CRP）、同型半胱氨酸（homocysteine，Hcy）、降钙素原（procalcitonin，PCT）比较差异均无统计学意义（P〉0．05），治疗后3个月两组患者的hs—CRP、Hcy、PCT均明显改善（P〈0．05），且2组比较差异有统计学意义（P〈0．05）；治疗前2组患者的躯体功能状态评估（Karnobsky，KPS）评分、精神心理状况采用汉密顿抑郁量表（HAMD）评分比较差异均无统计学意义（P〉0．05），治疗后3个月2组患者的KPS评分、HAMD评分均明显改善（P〈0．05），且2组比较差异有统计学意义（P〈0．05）。结论常规血液透析与血液灌流应用于ESRD均能有效改善患者的肾功能，但后者能够更好地改善患者的微炎症状态、提高生活质量，是临床优选的治疗方案。
Objective To observe the impact of conventional hemodialysis and hemoperfusion on micro-inflammatory state of patients with end-stage renal disease. Methods From January 2012 to October 2013 in our hospital, 68 cases of end-stage renal disease were selected as the research subjects.. 32 cases subject to conventional hemodials）sis as the control group, and 36 cases subject to hemoperfusion as the observation group. The improvement data of renal function, micro-inflammatory state and quality of life of two groups before and after treatment were observed and compared. Results Before treatment, there was no significant difference in glomerular filtration rate, blood urea nitrogen and serum creatinine between two groups （P〉0. 05）. After three months of treatment, the glomerular filtration rate was significantly increased, and blood urea nitrogen and serum creatinine were significantly reduced in two groups （P〈0. 05）, and there was no significant difference between two groups （P〉 0. 05）. Before treatment, there was no significant difference in high-sensitivity C-reactive protein, ho- mocysteine and procalcitonin between two groups （P〉0. 05）. After three months of treatment, the high-sensitivity C-reactive protein, homocysteine, and procalcitonin in two groups were significantly reduced （P〈0. 05）, and the difference was statistically significant between two groups （P〈0. 05）. Before treatment, there was no significant difference in physical function status of patients [Karnofsky （KPS） scores], and psychological status [Hamilton Depression Scale （HAMD） scores] between two groups （P〉0.05）. After three months of treatment, the KPS scores and HAMD scores in two groups got significantly improved （P〈0. 05）, and the difference was statistically significant between two groups （P〈0. 05）. Conclusions Conventional hemodialysis and hemoperfusion can effectively improve renal function in patients with end-stage renal disease, but the latter is more satisfactory to improv
出处
《临床肾脏病杂志》
2015年第8期489-492,共4页
Journal Of Clinical Nephrology
关键词
终末期肾脏病
血液透析
血液灌流
肾功能
微炎症状态
End-stage renal disease
hemodialysis
Hemoperfusiom Renal functiom Microinflammation
