摘要
目的观察盐酸羟考酮注射液预先给药用于腹腔镜胆囊切除术的麻醉效果。方法选择择期在全身麻醉下行腹腔镜胆囊切除术患者50例，ASA分级Ⅰ～Ⅱ级，年龄22—60岁。随机分为盐酸羟考酮组（O组，25例）和生理盐水对照组（C组，25例），分别静脉注射盐酸羟考酮注射液0．1mg／kg（稀释至6m1）及等容量的生理盐水。5min后均静脉注射咪达唑仑0．05mg／kg，丙泊酚1．5mg／kg（注射时间5S），芬太尼3μg/kg（注射时间3s），罗库溴铵0．8mg／kg。观察丙泊酚注射痛、注射芬太尼后2min内呛咳的发生频率和程度及苏醒后2h、6h、12h、24h的静态、动态疼痛数字等级评分（NRS）和Ramsay镇静评分。结果与C组比较，O组患者丙泊酚注射痛减轻（P〈0．05）；呛咳发生率降低、程度减轻（P〈0．05）；术后各时间点静态、动态NRS降低（P〈0．05），各时间点Ramsay镇静评分比较差异无统计学意义（P〉0．05）。结论静脉注射盐酸羟考酮0．1mg／kg可有效抑制丙泊酚注射痛，减缓因注射芬太尼所致呛咳的发生，减缓术后疼痛，且不产生过度镇静。
Objective o observe the anesthesia effects of oxycodone hydrochloride pretreatment during laparoscopic cholecystectomy. Methods Fifty ASA Ⅰ - Ⅱ patients, aged 22-60 years, were scheduled for elective laparoscopic cholecystectomy. Patients were randomly divided into 2 groups （ n = 25 in each） ： physiological saline control group （ group C ） and oxycodone hydrochloride group （ group O ）. Two groups were injected oxycodone hydrochloride or the same volumes of physiological saline （6 ml）. Five minutes later, the patients were injected with midazolam of 0. 05 mg/kg, propofol of 1.5 mg/kg（ the injection time is 5 seconds）, fentanyl of 3 μg/kg（ the injection time is 3 seconds）, and rocuronium of 0. 8mg/kg. Injection pain of propofol, and development and intensity of cough within 2 minutes after fentanyl injection were observed. Pain at rest and movement was evaluated using NRS score at 2 h,6 h,12 h and 24 h after surgery and Ramsay sedation score were recorded at the same time simultaneously. Results Compared with group C,injection pain of propofol significantly decreased in group O （ P 〈 0.05 ）, the incidence of cough was significantly decreased and the intensity of coughing was mitigated in group O（ P 〈 0.05 ）. NRS scores at rest and movement were decreased at 2 h, 6 h, 12h,24h after surgery in group O （P 〈 0.05 ）. There were no significant differences at each time point in Ramsay sedation score（P 〉0.05）. Conlusion Intravenous oxycodone hydrochloride（0.1 mg/kg）can suppress the injection pain of propofol, decrease the development and intensity of fentanyl-induced cough, relieve postoperative pain and do not produce excessive sedation.
出处
《临床外科杂志》
2015年第8期610-612,共3页
Journal of Clinical Surgery
关键词
羟考酮
注射痛
呛咳
oxycodone hydrochloride
injection pain
cough
