摘要
目的观察茶碱对支气管哮喘（简称哮喘）患者肺功能及IL-17、C反应蛋白（CRP）的影响。方法将120例哮喘患者随机分为对照组和治疗组各60例。对照组予以沙美特罗氟替卡松50／250μg每日2次吸入治疗；治疗组在对照组治疗基础上加用茶碱缓释片（0．1g每日2次口服）。2组治疗前均行肺功能及血IL-17、CRP检测。4周后复测肺功能及IL-17、CRP。结果治疗前2组肺功能及血IL-17、CRP比较差异无统计学意义（P〉0．05）；治疗后肺功能：FEV1％pred、FEV1／FVC、最大呼气流速％pred均改善，但2组间改善率比较，差异无统计学意义（P〉0．05），用力呼出气量为25％～75％肺活量时的平均流量（FEF25％-75％）占预计值百分比及FEF25％-75％／FVC明显高于对照组（P〈0．01），治疗组血IL-17、CRP水平下降高于对照组（P〈0．01）。结论茶碱能更好的控制哮喘患者的小气道功能及气道炎症，并改善气道高反应性。
Objective To observe the effect of theophylline on lung function and IL-17, CRP in patients with bronchial asthma （asthma）. Methods One hundred and twenty cases of asthma were randomly divided into control group and treatment group with 60 cases in each group. The control group was given Shah Metre Lo fluticasone 50/250μg 2 times daily inhalation therapy. The treatment group was treated with Theophylline Sustained-release Tablets on the basis of the control group （Orally 2 times daily 0.1 g）. The two groups were measured lung function and blood IL-17 ,CRP before treatment measurement of pulmonary function and 1L-17,CRP after 4 weeks. Results There are no significant difference of the two groups of lung function and blood IL-17, CRP before the treatmen （ P 〉0.05）. Pulmonary function after treatment： FEV1% pred, FEV1/FVC, PEF% pred have improved, But the two groups had no significant difference between the rate of improvement （ P 〉 0.05 ）, FEF25 %-75 % in predicted and FEF25 %-75 %/FVC were significantly higher than that of control group （ P 〈0.01）, the treatment group blood IL-17,CRP levels decreased than that of the control group （ P 〈0.01）. Conclusions Theophylline can better control small airway function and airway inflammation of in asthma patients, and improve the airway hyperresponsiveness.
出处
《国际呼吸杂志》
2015年第17期1289-1291,共3页
International Journal of Respiration
关键词
支气管哮喘
茶碱
肺功能
白介素17
C反应蛋白
Bronchial asthma
Theophylline
Pulmonary function
Interleukin-17
C-reactive protein
