摘要
目的:应用64层螺旋CT比较不同强度阿托伐他汀治疗对冠脉斑块的作用。方法:回顾性分析阿托伐他汀治疗的36例患者,共计45处非钙化冠脉斑块病变。依据治疗后低密度脂蛋白水平分为治疗达标组(17例)和治疗未达标组(19例)。比较两组病例治疗前、后血生化指标的变化。比较两组斑块治疗前、后脂质比例、血管重构系数、最小管腔直径、斑块长度和斑块体积。结果:治疗达标组低密度脂蛋白降幅为46.7%,大于治疗未达标组的30.1%(P<0.01)。两组的血管重构系数和斑块体积均可见减小的趋势,但均未见统计学差异(均P>0.05)。与治疗前比较,治疗达标组斑块脂质百分比降低了5.15%(P<0.01)。治疗未达标组斑块脂质比例治疗后未见明显变化(P>0.05)。结论:治疗达标组斑块脂质比例较治疗前明显降低,显示了阿托伐他汀稳定斑块性质的作用。
AIM： To compare the effect of different intensity atorvastatin therapies on the coronary plaques by 64-slices computer tomography. METHODS： 36 patients were retrospectively analyzed,and 45 plaques without calcification. The patients were divided into achieving target group and failing to achieve target group according to low-density lipoprotein cholesterol at follow-up. Achieving target group and failing to achieve target group had 17 and19 patients separately. The changes in serum lipid profile and CT parameters from baseline to follow-up between two groups were compared. RESULTS： The reduction of low-density lipoprotein cholesterol in achieving target group and failing to achieve target group were 46. 7% and 30. 1% separately. Followup low-density lipoprotein cholesterol were significantly lower in achieving target group compared with failing to achieve target group（ P〈0. 01）. Both remodeling index and plaque volume did not change from baseline to follow-up in both two groups. The ratio of lipid volume to plaque volume decreased 5.15% from baseline to follow-up in achieving target group（ P〈0. 01）. The ratio of lipid volume to plaque volume from baseline to follow-up did not change in failing to achieve target group. CONCLUSION： The decrease of the ratio of lipid volume to plaque volume from baseline to follow-up in achieving target group might indicate atorvastatin stabilize non-calcified coronary plaques.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2015年第8期938-942,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
武汉市卫生局临床医学科研项目(WX12B03)
