摘要
【目的】观察加味八珍汤对慢性再生障碍性贫血(CAA)患者骨髓液中成纤维细胞生长因子-1(FGF-1)的影响。【方法】将60例CAA患者随机分为治疗组和对照组各30例,对照组单纯给予常规西药治疗(包括口服康力龙和环孢素A等),治疗组给予加味八珍汤联合常规西药治疗,2组均以6个月为1个疗程。观察2组西医临床疗效、中医证候疗效、外周血象变化及不良反应情况,并检测2组骨髓液中FGF-1含量。【结果】(1)西医临床疗效:治疗组的总有效率为80.0%,优于对照组的66.7%(P<0.05)。(2)中医证候疗效:治疗组的总有效率为100.0%,优于对照组的83.3%(P<0.05)。(3)治疗后,2组患者的临床症状积分均较治疗前显著降低(P<0.05或P<0.01),且治疗组的降低作用优于对照组(P<0.05)。(4)治疗后,2组患者的外周血白细胞(WBC)、血红蛋白(HGB)、血小板(PLT)及骨髓液中FGF-1水平均得到显著提升(P<0.01),且治疗组的改善作用均优于对照组(均P<0.05)。(5)不良反应:治疗组肝功能损害2例,痤疮、多毛1例;对照组齿龈增生2例,肝功能损害5例,痤疮、多毛4例。对照组的不良反应发生率高于治疗组(P<0.05)。【结论】加味八珍汤治疗CAA有良好的疗效,可能是通过提高FGF-1来改善患者的造血微环境,但其具体的作用机理还需进一步研究。
Objective To observe the effect of modified Bazhen Decoction （ MBD） on bone marrow fibroblast growth factor-1 （ FGF-1） in chronic aplastic anemia （ CAA） patients. Methods Sixty cases of CAA were randomly divided into treatment group and control group, 30 cases in each group. Both groups were given conventional western medicine such as oral use of Stanozolol and Ciclosporin, and additionally, the treatment group received oral use of MBD. Six months constituted one treatment course for both groups. After treatment, the clinical efficiency in western medicine field and on Chinese medical syndromes was evaluated in both groups. The changes of peripheral hemogram, adverse reaction, and FGF-1 in the bone marrow of both groups were also monitored. Results （ 1） Clinical efficacy in western medicine field was 80.0% in the treatment group, and was 66.7%in the control group （P〈0.05）. （2） The total effective rate on Chinese medical syndromes was 100.0% in the treatment group, and was 83.3%in the control group （P〈0.05）. （3） After treatment, the scores of symptoms were decreased in both groups （P〈0.05 or P〈0.01 compared with those before treatment）, and the decrease in the treatment group was superior to that in the control group （P〈0.05）. （4） Peripheral white blood cell （WBC） count, hemoglobin （HGB） content and platelet （PLT） count as well as bone marrow FGF-1 were increased in both groups after treatment （P〈0.01 compared with those before treatment）, and the increase of WBC, HGB, PLT and FGF-1 in the treatment group was superior to that in the control group （P〈0.05）. （5） In the aspect of the adverse reaction, the treatment group had 2 cases of hepatic fucntion injury, and one case of acne and hairiness; the control group had 2 cases of gum hypertrophy, 5 cases of hepatic function injury, and 4 cases of acne and hairiness. The control group had higher incidence of adverse reaction （ P〈0.05）. Conclusion MBD exerts certain therapeutic effect
出处
《广州中医药大学学报》
CAS
2015年第5期830-833,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
