摘要
目的：探讨喉鳞状细胞癌组织中Dermol与N-cadherin、 E-cadherin的表达及意义。方法：应用免疫组织化学S-P法检测Dermol与N-cadherin、 E-cadherin在48例喉鳞癌组织及30例癌旁正常组织中的表达情况,分析它们在不同组织中的相互关系及与喉鳞癌临床参数的关系。结果： Dermol、 N-cadherin及E-cadherin在喉鳞癌及癌旁组织中的阳性表达率比较差异具有统计学意义（P〈0.05）；喉鳞状细胞癌中Dermol、 N-cadherin及E-cadherin的阳性表达率在有无淋巴结转移、临床分期组间差异有统计学意义（P〈0.05）；在不同年龄间差异无统计学意义（P＆gt;0.05）；喉鳞状细胞Der-mol的阳性表达与N-cadherin的阳性表达呈正相关（ r =0.390,P =0.016）,与E-cadherin的表达成负相关。结论： Der-mol与N-cadherin、 E-cadherin在喉鳞状细胞癌发生、分化程度、浸润及转移过程中起重要作用, Dermol与N-cadherin、E-cadherin的协同作用可能影响喉鳞状细胞癌的转移。
OBJECTIVE： To investigate the expression and clinical significances of Dermol, N-cadherin and E-cadherin in la-ryngeal squamous cell carcinoma （ LSCC） . METHODS： The expression of Dermol, N-cadherin and E-cadherin were detected by immunohistochemistry S-P method in the tissue of 48 patients with LSCC and the tissue in 30 patients with tumor-adjacent normal. The relationship between three factors and clinical pathological features of LSCC was investigated. RESULTS： There were statistically significant in the differences of the positive rate of Dermol, N-cadherin and E-cadherin in LSCC and tumor-adjacent normal （ P〈0. 01）; There were statistically significant in the positive expression rate of Dermol, N-cadherin and E-cadherin in lympha node metastasis, clinical stage in LSCC （P〈0. 01）. There was no statistically significant difference between the different age groups （P＆gt;0. 05）. The positive expression of Dermol was negatively related to that of E-cadherin （ r = -0. 344, P =0. 034）. CONCLU-SION： Dermol, N-cadherin and E-cadherin play an important role in the occurrence, degree of differentiation, infiltration and metastasis of laryngeal squamous cell carcinoma. The synergistic effect of Dermol, N -cadherin and E -cadherin may have some effects on the infiltration and metastasis of laryngeal carcinoma.
出处
《国际老年医学杂志》
2015年第5期213-216,共4页
International Journal of Geriatrics
