摘要
目的：评价两种方案治疗宫颈癌骨转移患者的疗效及毒副反应。方法：回顾性收集资料完整的宫颈癌骨转移患者56例,按治疗方案分为放化疗组（31例）和双膦酸盐组（25例）,放化疗组患者采用放、化疗联合双膦酸盐治疗,双膦酸盐组采取双膦酸盐姑息对症治疗,3~4周为1个疗程,两组患者均治疗3个疗程。比较两组患者平均生存时间、生存质量及毒副反应。结果：宫颈癌骨转移后放化疗组患者平均生存时间为17月（95%CI：9.1~24.9）,双膦酸盐组为19月（95%CI：2.4~35.6）;3年生存率放化疗组患者为16.1%,双膦酸盐组为16.0%,组间比较差异均无统计学意义（P=0.820）。3个疗程后患者KPS评分比较,放化疗组患者改善率（22.6%）明显低于双膦酸盐组（40.0%）,差异有统计学意义（χ2=4.36,P〈0.05）;放化疗组毒副作用较双膦酸盐组明显。结论：双膦酸盐对患者生存质量影响较小,毒副反应不明显,临床上值得推荐给部分晚期、高龄、复发的宫颈癌转移患者。
OBJECTIVE：To evaluate therapuetic efficacy and toxic reaction of 2 therapuetic regimens for 56 cases of bone metastasis of cervical cancer. METHODS：56 cases of bone metastasis of cervical cancer with complete information were collected retrospectively and randomly divided into radiochemotherapy group（31 cases）and diphosphonate group（25 cases）. Radiochemotherapy group was given radiotherapy,chemotherapy and diphosphonate;diphosphonate group was given palliative symptomatic treatment of diphosphonate;a treatment course lasted for 3-4 weeks,and both groups received 3 courses of treatment. Average survival time,survival quality and toxic reaction were comparison in 2 groups. RESULTS：After bone metastasis of cervical cancer,the average survival time of radiochemotherapy group was 17 months（95% CI：9.1-24.9）,and that of diphosphonate group was 19months（95% CI：2.4-35.6）;3 years later,the survival rate of radiochemotherapy group was 16.1%,and that of diphosphonate group was 16.0%,there was no statistical significance（P=0.820）. To compared KPS after 3 treatment courses,the improvement rate of radiochemotherapy group（22.6%）was significantly lower than that of diphosphonate group（40.0%）,with statistical significance（χ2=4.36,P0.05）. Toxic reaction of radiochemotherapy group was more significant than that of diphosphonate group.CONCLUSIONS：Diphosphonate has little effect on survial quality and slight toxic reaction. It is worthy of spreading in some patients with advanced,elderly and reccurred bone metastasis of cervical cancer.
出处
《中国药房》
CAS
北大核心
2015年第26期3681-3683,共3页
China Pharmacy
关键词
宫颈癌
骨转移
双磷酸盐
Cervical cancer
Bone metastasis
Diphosphonate
