摘要
目的:为临床合理使用抗菌药物提供参考。方法:抽取我院呼吸科抗菌药物专项整治前(2013年9月-2014年4月)、后(2014年5-12月)收治的慢性阻塞性肺疾病急性加重期(AECOPD)患者住院病历各73份和88份,对比分析抗菌药物的使用情况,评价AECOPD患者药品使用的合理性。结果:开展抗菌药物专项整治活动后,我院AECOPD患者的抗菌药物使用强度从217.74下降至91.58,联合使用抗菌药物率由67.12%下降至6.82%,无理由更换抗菌药物率由15.07%下降至0,患者住院时间由(10.21±3.44)d缩短至(7.13±3.14)d,医疗总费用由(6 117.73±1 164.52)元减少至(4 574.82±997.28)元,药费和抗菌药费所占百分比分别由(61.83±11.49)%和(28.84±9.55)%下降至(43.52±9.97)%和(20.07±6.43)%,各项指标比较差异均具有统计学意义(P<0.05),且临床治疗效果未受影响。结论:开展抗菌药物专项整治可有效提高抗菌药物的合理使用率,增强抗菌药物的针对性,节约患者的医疗成本。
OBJECTIVE：To provide reference for the rational application of antimicrobial drugs. METHODS：Medical records of all acute exacerbation of chronic obstructive pulmonary disease（AECOPD）hospitalized patients were collected from respiration department of our hospital during Sept. 2013 to Apr. 2014 and May 2014 to Dec. 2014,73 and 88 cases respectively. The application of antimicrobial drug was analyzed comparatively,and the rationality of drug use in AECOPD patients was evaluated. RESULTS：After the special rectification activities,the antimicrobial use intensity dropped from 217.74 to 91.58;drug combination rate dropped from 67.12% to 6.82%;no reason to change the antimicrobials conditions dropped from 15.07% to 0;hospital stay shortened from（10.21±3.44）d to（7.13±3.14）d;the total cost of medical treatment dropped from（6 117.73±1 164.52）yuan to（4 574.82±997.28）yuan;percentage of medicine expenses and antimicrobial drug expenses dropped from（61.83±11.49）% and（28.84±9.55）% to（43.52±9.97）% and（20.07±6.43）%,respectively;there was statistical significance（P0.05）,and the clinical treatment effect were uninfluenced. CONCLUSIONS：The special rectification activities of antimicrobial drugs could effectively improve the rational application of antimicrobial drugs and enhance the efficacy of antimicrobial drugs and decrease the cost of drug use.
出处
《中国药房》
CAS
北大核心
2015年第26期3625-3627,共3页
China Pharmacy
关键词
慢性阻塞性肺疾病
急性加重期
抗菌药物专项整治
合理用药
Chronic obstructive pulmonary disease
Acute exacerbation
Special rectification activities
Rational drug use
