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Ubiquitin homeostasis: from neural stem cell differentiation to neuronal development

Ubiquitin homeostasis: from neural stem cell differentiation to neuronal development
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摘要 Ubiquitin(Ub)is a well-known eukaryotic protein that exerts diverse signaling functions inside the cells,including targeting its substrates for proteasomal degradation(Hershko and Ciechanover,1998). Ubiquitin(Ub)is a well-known eukaryotic protein that exerts diverse signaling functions inside the cells,including targeting its substrates for proteasomal degradation(Hershko and Ciechanover,1998).
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第8期1209-1210,共2页 中国神经再生研究(英文版)
基金 supported by a grant from the Korean Health Technology R&D Projects,Ministry of Health&Welfare,Republic of Korea(HI14C2300)to KYR
关键词 Ubiquitin neuronal homeostasis eukaryotic sequential targeting diverse suppression maintain impaired Ubiquitin neuronal homeostasis eukaryotic sequential targeting diverse suppression maintain impaired
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参考文献12

  • 1Bi F, Huang C, Tong J, Qiu G, Huang B, Wu Q, Li F, Xu Z, Bowser R, Xia XG, Zhou H (2013) Reactive astrocytes secrete lcn2 to promote neuron death. Proc Natl Acad Sci U S A 110:4069-4074. 被引量:1
  • 2Hanna J, Leggett DS, Finley D (2003) Ubiquitin depletion as a key mediator of toxicity by translational inhibitors. Mol Cell Biol 23:9251-9261. 被引量:1
  • 3Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425-479. 被引量:1
  • 4Kimura Y, Yashiroda H, Kudo T, Koitabashi S, Murata S, Kakizuka A, Tanaka K (2009) An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis. Cell 137:549-559. 被引量:1
  • 5Komander D, Clague MJ, Urbe S (2009) Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol 10:550-563. 被引量:1
  • 6Park CW, Ryu KY (2014) Cellular ubiquitin pool dynamics and homeostasis. BMB Rep 47:475-482. 被引量:1
  • 7Park CW, Ryu HW, Ryu KY (2012) Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb. Biochem Biophys Res Commun 418:541-546. 被引量:1
  • 8Ryu HW, Park CW, Ryu KY (2014a) Restoration of cellular ubiquitin reverses impairments in neuronal development caused by disruption of the polyubiquitin gene Ubb. Biochem Biophys Res Commun 453:443-448. 被引量:1
  • 9Ryu HW, Park CW, Ryu KY (2014b) Disruption of polyubiquitin gene Ubb causes dysregulation of neural stem cell differentiation with premature gliogenesis. Sci Rep 4:7026. 被引量:1
  • 10Ryu KY, Garza JC, Lu XY, Barsh GS, Kopito RR (2008) Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene. Proc Natl Acad Sci U S A 105:4016-4021. 被引量:1

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