摘要
[目的]探讨布地奈德直肠给药治疗远端溃疡性结直肠炎患者的临床疗效及对P-选择素、ICAM-1表达影响。[方法]选取我院收治的82例远端溃疡性结直肠炎患者为研究对象,采用随机数字表法分为观察组和对照组各41例,观察组采用布地奈德混悬液保留灌肠,对照组采用地塞米松保留灌肠。比较2组治疗效果、P-选择素(P-sel)、ICAM-1表达水平及免疫组化结果。[结果]观察组治疗疗效明显高于对照组(92.68%vs.80.49%);P-sel、ICAM-1明显低于对照组[(18.65+3.12)vs.(24.34+4.05),(230.12+16.45)vs.(286.65+20.14)]ng/L;P-sel(++)表达强度明显低于对照组。[结论]布地奈德直肠给药有助于下调组织中黏附分子P-sel、ICAM-1表达水平,缓解炎症反应,提高治疗效果。
[Objective]To study the effect of topical administration of budesonide on distal ulcerative colitis or proctitis as well as the influence on P-selectin and ICAM-1expression.[Methods]Eighty-two cases of patients with distal ulcerative colitis or proctitis were divided into observation group and control group,given budesonide suspension fluid or dexamethasone retention enema,respectively.The curative effects and the expression of P-sel and ICAM 1as well as immunohistochemical results were compared between the two groups.[Results]The curative effect in observation group was significantly higher than that of control group（92.68% vs 80.49%）.The levels of P-sel and ICAM-1were significantly lower than those of control group[（18.65＋3.12）vs.（24.34＋4.05）,（230.12＋16.45）vs.（286.65＋20.14）]ng/L.P-sel（＋＋）expression intensity was significantly lower than that of control group.[Conclusion]Topical budesonide administration is able to downregulate P-sel and ICAM 1expression level,alleviate inflammation,thus improve the effect of treatment.
出处
《中国中西医结合消化杂志》
CAS
2015年第8期549-552,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
广东省深圳市宝安区科技创新局技术项目(No:2014239)
