摘要
背景与目的:肺癌是目前我国乃至全球发病率和死亡率最高的恶性肿瘤,多数患者在60岁之后发病,因此对老年患者行肺癌手术是临床非常值得关注的问题。本研究探讨上海肺科医院行肺癌切除手术的老年与中年肺癌患者的临床特征、流行病学特点及围手术期的情况,为临床诊疗提供参考。方法:回顾性分析2007年1月—2012年12月在上海市肺科医院胸外科住院并接受手术的1 019例肺癌患者,比较老年组和中年组在性别、病理类型、TNM分期、术中出血量及术后住院天数等方面的差异。结果:两组性别分布差异有统计学意义(P<0.05),和中年组相比,老年组男性比例更高(76.91%vs 52.81%)。在病理类型上,两组均为腺癌最多、鳞癌次之,但病理类型构成比差异有统计学意义(P<0.05),老年组鳞癌的比例较中年组高(37.5%vs 15.6%),腺癌的比例较中年组低(50.7%vs 72.8%)。在临床分期构成比上,老年组病例中Ⅱa、Ⅱb、Ⅲa期的比例高于中年组,中年组病例中Ⅰa、Ⅰb期的比例高于老年组(P<0.05)。老年组患者术中出血量及术后住院天数均高于中年组患者,两组患者的术后平均住院时间差异有统计学意义(P<0.05)。两组伴随疾病差异有统计学意义(P<0.05),老年组伴随疾病的比例高于中年组(58.6%vs 42.3%)。结论:老年肺癌患者男性较多,病理类型以腺癌较多,来院就诊时以中晚期多见,术中出血量、术后住院天数均多于中年肺癌患者。
Background and purpose：The morbidity and mortality of lung cancer are currently the highest malignant tumor in China and the world. Most onset age of the illness is after 60 years old. Therefore, surgical resection of lung cancer in the elderly is very worthy of concern. This study aimed to investigate the clinical features, epidemic characteristics and conditions in perioperative period between the elderly and middle-aged patients with lung cancer, and provide the reference for clinical treatment.Methods：Totally 1 019 patients with lung cancer who were admitted to the hospital and accepted the operations in department of thoracic surgery in Shanghai Pulmonary Hospital from Jan. 2007 to Dec. 2012 were analysed retrospectively. The clinical data including gender, pathological type, TNM stage, intraoperative amount of bleeding and post-operative length of hospitalization were compared.Results：There was a signiifcant difference in sexual factors between these two groups （P？0.05）, and compared with the middle-aged group, the proportion of male was more higher in the elderly group （76.91%vs 52.81%）. Adenocarcinoma was the most common and squamous carcinoma was the next in both two groups. The constituent ratio of the pathlogical type between the elderly group and the middle-aged group was statistically signiifcant （P？0.05）. The squamous carcinoma in the elderly group was higher than that in the middle-aged group （37.5%vs 15.6%）. On the contrary, adenocarcinoma was more common in the middle-aged group （72.8%vs 50.7%）. StagesⅡa,Ⅱb, andⅢa were more common in the elderly group and stagesⅠa, andⅠb were the most clinical stage in the middle-aged group. The clinical stage between two groups was statistically significant （P？0.05）.The intraoperative amount of bleeding was higher and the post-operative length of hospitalization was longer in the elderly group, with a signiifcant difference as compared with that in the middle-aged group（P？0.05）. And there was a signiifcant diff
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2015年第8期624-628,共5页
China Oncology
关键词
肺癌
老年
临床特征
Lung cancer
The elderly
Clinical characteristic
