摘要
目的：探讨呼出气一氧化氮浓度（FeNO）在慢性阻塞性肺疾病急性期（AECOPD）患者中的变化情况及与一秒用力呼气容积（FEVl）的关系。方法：选取上海第九人民医院2013年8月～2014年2月呼吸内科病区治疗的AECOPD患者30例，目前仍在吸烟或患有哮喘、自身免疫性疾病及肿瘤的患者排除在外。对照组选取18例健康的体检老年人。入组患者在治疗前先测定FcNO、FEVl值及完成CAT评分，并进行病情分组。治疗后再次测定FeNO、FEV1％值。结果：治疗前实验组FeNO、FEV1％水平与对照组相比有统计学差异（P〈0．01）。治疗后实验组FeNO与对照组相比，无统计学差异（P〉0．05）。而治疗前后两组间FEVI％变化有统计学差异（P〈0．01）。实验组不同亚组治疗前后FeNO、FEVl％变化有统计学差异（P〈0．05），且治疗前FeNO与FEVl％呈负相关（γ=0．098，P=0．042），治疗后FeNO与FEV1％无明显相关（γ=0．248，P=0．784）。结论：FeNO可反映COPD急性期患者气道慢性炎症控制情况，且对提示预后有一定意义。
Objective： To evaluate the clinical significance of fractional exhaled nitric oxide （FeNO） in patients with acute exacer- bation of chronic obstructive pulmonary disease （AECOPD）, and to evaluate the correlation between FeNO and FEV1%. Methods： 30 pa- tients with AECOPD were selected as the experience group from August 2013 to February 2014 treated in the department of respiration in Shanghai the ninth People＇s Hospital. These patients suffered fi＇om asthma and tumor and autoimmune diseases was excluded as the same as smoking. 18 old healthy people were selected as the control group. The FeNO and FEV1% were examined before the treatment as soon as the CAT scale was completed to discriminate severity of AECOPD. The FeNO and FEVI% were examined after treatment again. Results： The FeNO and FEV1% was different between control group and experience group before the treatment （P〈0.01）. After the treatment, the change, of FeNO in experience group was not different compared with the control group （P〉0.05）, but the change of FEVI% was different （P〈0.01）. The changes in experience group were different after the treatment （P〈0.05）. Before the treatment there is a negative correlation between FeNO and FEV1% （γ=-0.098, P=0.042）. After the treatment there is not any correlation between FeNO and FEV1%（γ=-0.248,P=0.784）. Conclusions： FeNO can be considered as a marker of airway inflammation, and can be used in fore- casting the prognosis in patients with AECOPD.
出处
《现代生物医学进展》
CAS
2015年第21期4074-4077,共4页
Progress in Modern Biomedicine
基金
上海市卫计委<青年医师培养资助计划>
