摘要
目的:研究老年上消化道出血发病因素及与HP感染的相关性。方法:选取我院以消化性溃疡为诊断而收入院患者300例,进行钡餐及胃镜检查,其中合并出血者125例,未合并出血者175例,对照组选用相同时期出现消化道疾病且经胃镜检查排除消化性溃疡者310例。检测所有患者HP感染的情况和服用非甾体类抗炎(NSAIDs)药物的情况,根据是否服药及服用时间的长短分为ABCD组。测定消化性溃疡组与对照组中暴露人数与非暴露人数的比值比即OR值,并进行统计学分析。结果:1发生消化性溃疡的OR值,HP合并NSAIDs组为20.31,明显高于HP组和NSAIDs组,且大于两者之和,差异有统计学意义(P<0.05);2消化性溃疡合并出血与服用NSAIDs药物时间的关系显示,B组的OR值为3.79,C组的OR值为7.88,D组的OR值为10.41,B组<C组<D组,差异有统计学意义(P<0.05);3发生消化性溃疡合并出血的OR值,HP合并NSAIDs组为13.31,明显高于HP组的1.12和NSAIDs组的1.54,且大于两者之和,差异有统计学意义(P<0.05)。结论:老年上消化道出血的发病主要与消化性溃疡有关,HP感染与服用NSAIDs药物在发病过程中具有协同作用。
Objective： To study the risk factors in elderly upper gastrointestinal bleeding and the correlation with HP infection Methods： 300 cases of peptic ulcer patients diagnosed by barium meal, and gastroscopy in our hospital were selected as objects, which included 125 cases that combined with hemorrhage, and 175 cases without hemorrhage. And 310 cases exclusive of peptic ulcer in the same period by endoscopy were considered as control group. HP infection and use of non steroidal anti-inflammatory drugs （NSAIDs） were detected and carried on statistics analysis. Results： ①The OR value of incidence of peptic ulcer in HP combined with NSAIDs group was 20.31, obviously higher than that of liP group 6.97 and NSAIDs group 6.73, and more than the sum of the two, the difference was statistically significant （P〈0.05）;②for the relationship between peptic ulcer combined with hemorrhage and NSAIDs drug dose and time, the results showed the OR value in B group was 3.79, and 7.88 in C group, 10.41 in D group, group B 〈group C 〈group D, the difference was statistically significant （P〈0.05）; ③for the occurrence of peptic ulcer combined with hemorrhage, the OR value in HP combined with NSAIDs group was 13.31, significantly higher than that of group HP 1.12 and group NSAIDs 1.54, and more than the sum of the two, the difference was statistically significant （P〈0.05）. Conclusions： The occurrence of elderly upper gastrointestinal hemorrhage is mainly associated with peptic ulcer, and the infection of HP and taking NSA1Ds drugs, have synergistic effect in the course of disease.
出处
《现代生物医学进展》
CAS
2015年第19期3724-3727,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81070312)
关键词
老年上消化道出血
发病因素
HP感染
相关性
Elderly upper gastrointestinal bleeding
Risk factors
HP infection
Correlation
