摘要
目的了解阿片类毒品成瘾者参加美沙酮替代治疗(MMT)的治疗趋势及其影响因素。方法采用回顾性队列研究,对广西MMT门诊2006年入组的阿片类毒品成瘾者进行随访,数据来源于广西艾滋病综合防治信息系统。研究对象的基本特征、治疗趋势及影响因素等资料进行统计学描述及多因素Logistic回归分析。结果2013年12月31日随访终点时,1919名研究对象中,仍在治疗、退出治疗及死亡的人数分别为781人(40.7%)、993人(51.7%)、145人(7.6%)。随访期间有≥2个治疗阶段的比例占66.8%(1282人),第1、第2及第3治疗阶段的平均治疗时间分别为(18.1±17.3)、(16.6±14.6)及(11.9±10.6)个月;但其重新入组治疗的时间间隔随着退出治疗次数的增多呈现缩短的趋势。多因素Logistic回归分析结果显示,艾滋病病毒(HIV)阳性入组、工薪人员、服药时间≥1年,是阿片类毒品成瘾者连续治疗的保护因素;而独居及治疗期间尿检阳性率≥11%,是其连续治疗的危险因素。结论广西阿片类毒品成瘾者在MMT期间反复"入组治疗-退出治疗"的情况普遍存在,亟须采取针对性干预措施降低该现象对MMT良好效果的影响。
Objective To learn the therapeutic dynamics and influencing factors among opioid addicts who enrolled in methadone maintenance treatment（MMT）clinics.Methods A retrospective cohort study was conducted among opioid addicts who enrolled in MMT clinics in Guangxi in 2006.Data were collected using Guangxi information system of HIV/AIDS comprehensive prevention and control.The subject＇s characteristic,therapeutic dynamics and influencing factors were analyzed by descriptive analysis and multivariate logistic regression analysis.ResultsBy the end of 31,Dec.2013,of 1919 subjects.the number of subjects remained in treatment,dropped out of treatment and died were 781（40.7%）,993（51.7%）and 145（7.6%）,respectively.66.8%（1282）subjects had two or more treatment episodes during the follow-up period,the mean treatment time at 1-,2-and 3-episodes were（18.1±17.3）,（16.6±14.6）and（11.9±10.6）months,respectively.The time interval between drop out and re-entering treatment was shorten as the increasing times of drop out.Multivariate logistic regression analysis results showed that protective factors of continuous treatment of opioid addicts included HIV infection at baseline,having occupation during treatment and having taken methadone for one or more years.While living alone and more than 11% of positive urine test results during treatment were risk factors for continuous treatment.Conclusion Re-entering and dropping out was prevalent among Guangxi opioid addicts who enrolled in MMT clinics during follow-up.Tailored intervention measures to reduce the effect of this phenomenon on the positive role of MMT was urgent needed.
出处
《中国艾滋病性病》
CAS
北大核心
2015年第8期680-683,共4页
Chinese Journal of Aids & STD
基金
国家"十二五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10001-007)~~
关键词
美沙酮替代治疗
阿片类毒品成瘾者
治疗情况
Methadone maintenance treatment
Opioid dependence
Therapeutic dynamics
