摘要
目的 观察0.1％双氯芬酸钠眼液对视网膜光凝过程中疼痛程度的影响.方法 将86例患者分为两组,A组45例患者患增殖性糖尿病视网膜病变,给予每周1次视网膜光凝术,共两次.B组41例患者患非增殖性糖尿病视网膜病变合并黄斑水肿,19例为双眼,22例为单眼,给予黄斑格栅样光凝,0.1％双氯芬酸钠眼液和0.9％氯化钠注射液视网膜光凝前30 rmin点眼.行两次激光光凝患者第1次和第2次随机应用不同药物.应用视觉模拟评分法（visual analogue scale,VAS）对疼痛反应进行评估,数据进行统计学分析.结果 A组患者90次光凝中85次（94％）出现疼痛,其中应用0.1％双氯芬酸钠眼液平均疼痛水平为44.2％,应用氯化钠注射液的患者平均疼痛水平为53.1％ （P=0.011）.B组60次光凝中有16次（26.7％）出现疼痛,疼痛程度10％～ 60％不等,两组疼痛的程度与激光斑数量、激光光凝的能量无明显相关性.结论 0.1％双氯芬酸钠眼液可明显减轻视网膜光凝的疼痛程度.
Objective To evaluate the analgesic effect of sodium diclofenac 0.1% on retinal laser photocoagulation.Methods Among the 86 patients,45 patients with proliferative diabetic retinopathy were treated by two sessions of panretinal photocoagulation （group A）,and 41 patients with nonproliferative diabetic retinopathy underwent grid treatment of the posterior pole （19 bilaterally） （group B）.Sodium diclofenac 0.1% or sodium chloride 0.9% drops were topically applied 30 minutes before laser treatment in a masked fashion.Patients who had two sessions were given the alternate drug in the second one.Pain level was evaluated immediately after laser treatment with the visual analogue scale （VAS）.The results were statistically analyzed.Results Patients in group A had pain in 85/90 sessions （94%）.The average pain level was 44.2% with sodium diclofenac 0.1% drops and 53.1% with sodium chloride 0.9% drops （P =0.011）.Patients in group B had pain in only 16/60 sessions （26.7%）,and the pain level ranged from 10% to 60% regardless of the kind of drops used.There was no correlation in either group between level of pain and average energy level used （160-380 mW）.Conclusions Sodium diclofenac 0.1% is useful for pain reduction and should be applied before panretinal photocoagulation.
出处
《中国实用医刊》
2015年第17期95-96,共2页
Chinese Journal of Practical Medicine
