摘要
<正>目前鼻咽癌公认和有效的治疗手段为放射治疗,或以放射治疗为主的综合治疗。但鼻咽癌组织中存在一定比例对放射线耐受的细胞,其是鼻咽癌局部残留、复发及远处转移的主要原因〔1〕。因此鼻咽癌的放射增敏性是提高其治愈率和控制率的有效手段。microRNA(miRNA)
Summary Radiotherapy is the primary treatment for nasopharyngeal carcinoma, and the disease control rate and survival time are able to be greatly improved by enhancing the radiosensitivity. Via mechanisms such as bind- ing to target genes mRNA 3runtranslated region （3~UTR）, microRNA （miRNA） inhibits translation,which there- fore regulates transcription of target genes and thus affect target protein expression. Recent research showed that miRNAs play significant roles in improvement of radiosensitivity in nasopharyngeal carcinoma. This article reviews mechanism of miRNA action to strengthen radiosensitivity of nasopharyngeal carcinoma and the future of clinical practice of miRNA in this disease.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2015年第17期1574-1576,共3页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
江苏省2014年省级条件建设与民生科技专项资金:鼻咽癌规范化诊疗新体系的建立及其基础临床研究(No:BC2014091)
