摘要
目的:探讨早期肠内营养护理在改善胃癌患者术后康复效果及免疫功能中的应用效果.方法:按照实际治疗情况将唐山市工人医院收治的胃癌患者105例分为观察组53例和对照组52例,观察组患者术后采取早期肠内营养,对照组患者术后采取肠外营养,记录两组患者术后排气恢复时间、住院时间并比较两组患者术前、术后1 wk CD3+、CD4+、CD8+、CD4+/CD8+、自然杀伤细胞(natural killer,NK)、免疫球蛋白A(immunoglobulin A,IgA)、IgG、IgM水平变化情况以及血清白蛋白(albumin,ALB)、前白蛋白(prealbumin,PAB)、转铁蛋白(transferrin,TFN)、血红蛋白、体质量变化情况.结果:对照组患者术后1 wk CD3+、CD4+、CD4+/CD8+、NK、IgA、IgG、IgM水平与术前比较差异有统计学意义(42.29%±4.66%vs 48.99%±5.13%、27.57%±3.68%vs 34.09%±3.88%、1.01±0.33 vs 1.19±0.29、15.58%±3.87%vs 22.88%±4.73%、1797.44 mg/L±251.78 mg/L vs 1824.17 mg/L±241.19 mg/L、8422.75 mg/L±204.76 mg/L vs 8549.96 mg/L±218.43 mg/L)、(1287.59mg/L±231.66 mg/L vs 1389.88 mg/L±214.39 mg/L)(P<0.05);观察组患者术后1 wk CD3+、CD4+、CD4+/CD8+、NK、IgA、IgG、IgM水平与对照组比较差异有统计学意义(48.09%±4.17%vs 42.29%±4.66%、33.18%±2.79%vs 27.57%±3.68%、1.19±0.27 vs 1.01±0.33、23.79%±3.99%vs15.58%±3.87%、1801.99 mg/L±214.28mg/L vs 1797.44 mg/L±251.78 mg/L、8519.93 mg/L±200.65 mg/L vs 8422.75 mg/L±204.76 mg/L、1377.93 mg/L±205.77 mg/L vs 1287.59 mg/L±231.66 mg/L)(P<0.05);观察组患者术后排气恢复时间及住院时间均显著短于对照组(1.79 d±0.44 d vs 2.51 d±0.52 d、10.79 d±2.22 d vs 15.74 d±3.88d)(P<0.05);对照组患者术后1 wk ALB、PAB、TFN及体质量水平均显著低于术前(28.19 mg/L±2.86 mg/L vs 32.04 mg/L±4.17mg/L、218.29 mg/L±14.91 mg/L vs 225.57mg/L±15.38 mg/L、158.29 mg/L±11.13mg/L vs 162.05 mg/L±13.28 mg/L、58.77kg±2.54 kg vs 62.69 kg±3.59 kg)(P<0.05);观察组患者术后1 wk ALB、PAB、TFN及体质量水平均显著优�
AIM： To assess the effect of early postoperative enteral nutrition on nutrition status and immune function in gastric cancer patients. METHODS： One hundred and five patients with gastric cancer after surgery were divided into an observation group （53 cases） and a control group （52 cases）. The observation group receivedearly enteral nutrition, and the control group received parenteral nutrition. The time to first anal exhaust, hospital stay, the percentages of CD3^±, CD4^±, and CD8^± lymphocytes, CD4^± CD8^± ratio, natural killer （NK） cells, immunoglobulin A （IgA）, IgG, IgM, albumin （ALB）, prealbumin （PAB）, and transferrin （TFN） were compared for the two groups. RESULTS： The percentages of CD3^± and CD4^± lymphocytes, CD4^±/CD8^± ratio, NK cells, IgA, IgG, and IgM at 1 wk after operation for the control group were significantly lower than those before operation （42.29% ± 4.66% vs 48.99% ± 5.13%, 27.57% ± 3.68% vs 34.09% ± 3.88%, 1.01 ± 0.33 vs 1.19 ± 0.29, 15.58% ± 3.87% vs 22.88% ± 4.73%, 1797.44 mg/L ± 251.78 mg/L vs 1824.17 mg/L ± 241.19 mg/L, 8422.75 mg/L ± 204.76 mg/L vs 8549.96 mg/L ± 218.43 rag/L, 1287.59 mg/L ± 231.66 mg/L vs 1389.88 mg/L ~ 214.39 rag/L; P 〈 0.05）. The percentages of CD3^＋ and CD4^＋ lymphocytes, CD4^＋/CD8^＋ ratio, NK cells, IgA, IgG, and IgM at 1 wk after operation for the observation group were significantly higher than those for the control group （48.09% ± 4.17% vs 42.29% ± 4.66%, 33.18% ±2.79% vs 27.57% ± 3.68%, 1.19 ± 0.27 vs 1.01 ± 0.33, 23.79% ± 3.99% vs 15.58% ± 3.87%, 1801.99 mg/L ± 214.28 mg/L vs 1797.44 mg/L ± 251.78 mg/L, 8519.93 mg/L ± 200.65 mg/L vs 8422.75 mg/L ± 204.76 rag/L, 1377.93 mg/L ± 205.77 mg/L vs 1287.59 mg/L ± 231.66 mg/L; P 〈 0.05）. The time to first anal exhaust and hospital stay for the observation group were significantly shorter than those for the control group （1.79 d ± 0.44 d vs 2.51 d ± 0.52 d, 10.79 d ± 2.22 d vs 15.74 d ± 3.88 d; P 〈0.05）. The levels of ALB
出处
《世界华人消化杂志》
CAS
2015年第21期3451-3455,共5页
World Chinese Journal of Digestology
关键词
早期肠内营养
胃癌
营养状态
免疫功能
Early enteral nutrition
Gastric cancer
Nutritional status
Immune function
