摘要
目的探讨葡萄糖-6-磷酸脱氢酶(G6PD)缺乏与2型糖尿病的关系,为临床诊断、治疗和监测2型糖尿病提供参考依据。方法选取该院体检健康者173例设为对照组;符合世界卫生组织(WHO)诊断标准的2型糖尿病患者195例设为糖尿病组;选取G6PD缺乏病患者97例,其中单纯G6PD缺乏者82例设为单纯G6PD缺乏组;合并征患者17例,设为糖尿病伴G6PD缺乏组。对上述研究对象的G6PD活性及糖尿病相关检测指标进行测定并统计分析。结果与对照组相比,糖尿病组的G6PD活性和红细胞(RBC)计数偏高,差异具有统计学意义(P<0.05);两组G6PD活性与RBC计数均呈明显正相关(P<0.05)。对照组、糖尿病组、糖尿病伴G6PD缺乏组的糖化血红蛋白(HbA1c)与血浆纤维蛋白原(FBG)均呈明显正相关(P<0.05),G6PD缺乏组的HbA1c与FBG无相关性。糖尿病组G6PD缺乏的检出率为3.6%,对照组G6PD缺乏的检出率为1.1%;HbA1c≥6.5时,糖尿病组G6PD缺乏的检出率明显高于对照组,差异具有统计学意义(χ2=4.239,P=0.039)。结论糖尿病伴G6PD缺乏者的HbA1c不能反映真实血糖情况,糖尿病患者的G6PD缺乏发病率高于对照组。非G6PD缺乏的糖尿病患者其G6PD活性高于对照组,这可能与RBC水平有关,也可能是代偿性增高或者是糖尿病控制良好的指标,有待进一步研究。
Objective To explore the relationship between glucose-6-phosphate dehydrogenase deficiency and type 2 diabetes and to provide reference for clinical diagnosis,monitoring and treatment of Type 2 diabetes.Methods Subjects were selected from our hospital,including 173 cases of healthy volunteers assigned to the control group;1 95 cases with type 2 diabetes conforming to the diagnostic criteria of WHO were assigned to the diabetic group.97 cases were diagnosed with glucose-6-phosphate dehydrogenase deficiency in our hospital,of whom 82 cases were assigned to simple glucose-6-phosphate dehydrogenase deficiency group,and 1 7 cases were assigned to the diabetes with glucose-6-phosphate dehydrogenase deficiency group.The correlation of glucose-6-phos-phate dehydrogenase activity and diabetes was measured by each detected value.Results Compared with the control group,the glu-cose-6-phosphate dehydrogenase activity and RBC count in diabetic group were higher（P〈0.05）.Positive correlations between glu-cose-6-phosphate dehydrogenase activity and RBC count in the two groups were significant（P〈0.05）.HbA1c and FBG showed a significant positive correlation in the control group,diabetic group and diabeties with glucose-6-phosphate dehydrogenase deficiency group（P〈0.05）.But there was no significant correlation in the glucose-6-phosphate dehydrogenase deficiency group.The rate of screening for glucose-6-phosphate dehydrogenase deficiency in diabetes group was 3.6%,and the rate in the control group was 1. 1%.When HbAlc≥6.5%,the rate of screening for glucose-6-phosphate dehydrogenase deficiency in the diabetes group was signifi-cantly higher than that in the control group （χ^2 =4.239,P =0.039）.Conclusion The level of HbA1c is discordant with that of blood glucose in diabetic patients with glucose-6-phosphate dehydrogenase deficiency group.Diabetes leads to the increasement of the rate of glucose-6-phosphate dehydrogenase deficiency.The glucose-6-phosphate dehydrogenase activity of diabetic patients with non-gl
出处
《国际检验医学杂志》
CAS
2015年第16期2297-2300,共4页
International Journal of Laboratory Medicine
基金
中山市科技计划项目(20132A091)
关键词
葡萄糖-6-磷酸脱氢酶
缺乏
2
型糖尿病
关系
glucose-6-phosphate dehydrogenase
deficiency
type 2 diabetes
relationship
