摘要
目的:探讨盐酸美金刚对血管性痴呆(Va D)患者的临床疗效和对血清脑源性神经营养因子(BDNF)水平的影响。方法:采用随机双盲法将70例Va D患者分为治疗组和对照组,分别给予盐酸美金刚和安慰剂治疗6个月;分别于治疗前和治疗3、6个月给予简易精神状态检查(MMSE)、日常生活能力量表(ADL)评分和血清BDNF水平检测。结果:治疗后治疗组MMSE评分及血清BDNF水平明显提高,ADL评分明显下降(P<0.05或P<0.01);对照组以上各指标治疗前后差异无统计学意义。结论:盐酸美金刚对Va D患者认知、行为能力有改善作用,可能与提高血清BDNF水平有关。
Objective： To explore the clincal curative effect of hydrochloride and the change of serum level of brain derived neurotrophic factor（ BDNF） in patients with vascular dementia（ VaD）. Method： Using the randomized double blind method,the 70 VaD patients were divided into treatment group and control group; and treated by memantine hydrochloride and the placebo respectively for 6 months. All of the patients were assessed by mini mental dementia examination（ MMSE） and activities of daily living（ ADL）; and their serum brain derived neurotrophic factor（ BDNF） level was detected before treatment and 3,6 months after treatment. Results： Compared with before treatment,the score of MMSE and the level of serum BDNF in the treatment group were significantly higher,and the scores of ADL was significantly lower（ P〈0. 05 or P 〈0. 01）; but there were no significant change in the control group. Conclusion： Memantine hydrochloride can improve the cognitive and behavioral ability in VaD patients. Its may be related to increased the level of serum BDNF.
出处
《临床精神医学杂志》
2015年第4期271-272,共2页
Journal of Clinical Psychiatry
关键词
盐酸美金刚
血管性痴呆
脑源性神经营养因子
memantine hydrochloride
vascular dementia
brain derived neurotrophic factor
