摘要
目的:研究分析经阴道穿刺取卵(OPU)术中最佳卵泡冲洗次数。方法:回顾性分析在本中心因男方精子质量较差单因素寻求辅助生殖治疗且符合相关纳入标准的368例患者的相关临床数据,分析不同卵泡冲洗次数与卵母细胞回收数的相关性及不同卵泡冲洗次数下回收卵母细胞的质量。结果:共计回收1 996个卵母细胞,总回收率为(94.8±11.8)%;其中卵泡冲洗0次、1次、2次、3次、4次、≥5次对应的回收率分别为29.9%(598/1 996)、31.1%(620/1 996)、21.7%(433/1 996)、9.0%(180/1 996)、4.5%(90/1 996)、3.8%(75/1 996);冲洗次数≤3次和>3次,成熟卵率分别为84.1%(1 540/1 831)和12.1%(20/165),差异有统计学意义(P<0.05);卵子异常形态率分别为12.7%(233/1 831)和21.2%(35/165),差异有统计学意义(P<0.05)。结论:OPU术中卵泡冲洗可以提高卵母细胞的回收率,但反复多次的冲洗不能增加卵母细胞回收数目,同时可能增加卵母细胞形态异常的发生率,最佳卵泡冲洗次数应≤3次。
Objective： To explore the best follicular flushing time in ovum pick-up （OPU） by analyzing the oocyte retrieval with different follicular flushing times. Methods： A total of 368 patients who underwent IVF/ ICSI only due to oligo-, astheno-, and teratosperwia of the male sperm in our center were included in the study. Follicular flushing with different times was performed for retrieving oocytes. Results： A total of 1 996 oocytes were retrieved, and the total oocyte retrievel rate was （94.8±11.8）%. The oocyte retrieval with different follicular flushing times from 0 to 5 and more were 29.9%, 31.1%, 21.7%, 9.0%, 4.5%, 3.8%, respectively. Statistical differences were found in the mature oocyte retrieval rate （84.1% and 12.1%, respectively）, abnormal oocyte morphology retrieval rate （12.7% and 21.2%） between flushing ≤ 3 times group and 〉3 times group （P〈0.05）. Conclusion： Follicular flushing is necessary for oocyte retrieval, but the follicular flushing times should not be more than three times.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2015年第8期575-578,共4页
Reproduction and Contraception
关键词
卵泡冲洗
冲洗次数
卵母细胞回收
follicular flushing
flushing times
oocyte retrieval
