摘要
目的：探讨蒙脱石散和沙利度胺治疗复发性口腔溃疡的疗效。方法选取我院2013年1月～2014年1月收治的复发性口腔溃疡患者150例作为研究对象，随机分为治疗组和对照组，各75例，分别进行沙利度胺和蒙脱石散治疗。结果口腔溃疡患者150例用药后，溃疡面明显缩小，症状基本消失，能进食。比较两组患者治疗前后溃疡改善情况，差异有统计学意义（P＜0.05），两组患者在Ⅱ级水平上差异有统计学意义（P=0.043，t=1.435）。通过实验发现治疗后患者的TNF-α水平显著降低，差异有统计学意义（P＜0.05），但两组患者TNF-α降低程度不一，沙利度胺效果更优，差异有统计学意义（P＜0.05）。沙利度胺和蒙脱石散的总有效率分别为98.7%和97.3%。但从显效来看治疗组疗效明显优于对照组，差异有统计学意义（P=0.024，t=2.134）。结论蒙脱石散和沙利度胺治疗复发性口腔溃疡疗效显著，值得临床推广和使用，但沙利度胺疗效更优。
Objective Explore the montmorillonite powder and Sally amine curative effect analysis for the treatment of recurrent oral ulcer.methods Select our hospital from January 2013 to January 2014, 150 patients with recurrent oral ulcer as the research object, were randomly divided into treatment group and control group, all the 75 cases, respectively for Sally amine and montmorillonite powder treatment.Results 150 patients with oral ulcer after medication, ulcer surface signiifcantly narrowed, symptoms disappeared basically, can eat. Ulcers before and after treatment in both groups, the difference was statistically signiifcant （P〈0.05）, two groups of patients inⅡ level difference was statistically signiifcant （P=0.043,t=1.435）. Experiments found that after treatment the patient＆#39;s level of TNF alpha decreased significantly, the difference was statistically significant （P〈0.05）, but have different extent of the two groups of patients with TNF alpha, Sally amine effect is better, the difference was statistically signiifcant （P〈0.05）. Sally amine and smecta total effective rate was 98.7% and 97.3% respectively. But from the perspective effect were markedly improved the curative effect of treatment group was obviously better than control group, difference was statistically significant （P=0.024,t=2.134）.Conclusion Montmorillonite dispersed and Sally amine recurrent oral ulcer with obvious therapeutic effect, worth clinical promotion and use, but Sally amine curative effect is better.
出处
《全科口腔医学电子杂志》
2015年第4期88-90,共3页
Electronic Journal of General Stomatology
关键词
蒙脱石散
沙利度胺
复发性口腔溃疡
疗效
Montmorillonite powder
Sally degrees amine
Recurrent oral ulcer
Curative effect
