摘要
目的:观察绝经后女性高血压、心功能不全患者雌激素水平变化;探讨女性绝经后雌激素水平和高血压、心功能不全的相关关系。方法:选取甘肃省人民医院心内科和体检科绝经女性患者107例,分为对照组(37例)、高血压组(40例)和高血压合并心功能不全组(30例),同时测定雌二醇(E2)、脂质过氧化物(LPO)、血清总抗氧化能力(TAS)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、左室射血分数(LVEF)、N末端脑利钠肽前体(NT-proBNP)、肌酐、尿酸、空腹血糖及BMI等指标,并进行统计分析。结果:1高血压组E2、HDL-C、TAS、LVEF显著低于对照组(P<0.05),LPO显著高于对照组(P<0.01)。高血压合并心功能不全组E2、TAS、HDL-C、LVEF显著低于对照组和高血压组(P<0.01),LPO、LDL-C、NT-proBNP显著高于对照组和高血压组(P<0.05)。2各组间在年龄、肌酐、尿酸、空腹血糖及BMI指数等方面无显著性差异(P>0.05)。3经Pearson相关分析,E2与LPO之间呈负相关(r=-0.707,P<0.01),E2与TAS之间呈正相关(r=0.847,P<0.01),E2与TC之间呈负相关(r=-0.304,P<0.01),E2与LDL-C之间呈负相关(r=-0.823,P<0.01),E2与HDL-C之间呈正相关(r=0.887,P<0.01),E2与LVEF之间呈正相关(r=0.725,P<0.01),E2与NT-proBNP之间呈负相关(r=-0.766,P<0.01)。结论:雌激素可通过多种途径改善血管内皮功能、抑制心肌细胞肥大、减少心肌细胞凋亡,是女性高血压和心功能不全的保护性因素;雌激素可能降低了TC、LPO及LDL-C水平,并增高了TAS、HDLC水平,二者具有相关性;氧化与抗氧化能力失衡可能参与了绝经后女性高血压和心功能不全的发生发展。
Objective：In order to observe the changes of estrogen level in the postmenopausal women with es- sential hypertension and heart failure. To investigate the association between estrogen, essential hypertension and heart failure in the postmenopausal women. Method：A total of 70 postmenopausal patients from Gansu Province People＇s Hospital were divided into essential hypertension group （40 cases） and heart failure group （30 cases）, and another 37 cases of postmenopausal women from the physical examination center is the control group. Various medical tests were requested： estrogen （E2）, lipid peroxide （LPO）, total antioxidant status （TAS）, total choles- terol （TC）, low-density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C）,left ven- tricular ejection fraction（LVEF）, NT-proBNP, creatinine, uric acid, fasting blood glucose and BMI. Result： 1 Blood serum levels of E2, HDL-C, TAS and LVEF in hypertension group was significantly lower than the control group （P〈0.05）, and LPO was significantly higher than the control group （P〈0. 01）. Blood serum levels of E2, TAS, HDL-C and LVEF in heart failure group was significantly lower than the control group and the hypertensive group （P〈0. 01）, and the levels of LPO, LDL-C,NT-proBNP was significantly higher than the control group and hypertension group （P〈0. 05）. 2There was no significant difference between groups in age, creatinine, uric acid, fasting glucose and BMI（P〉0.05）. 3According to the Pearson correlation analysis, there is a negative correla- tion between E2 and LPO （r=-0. 707,P〈0. 01）,E2 and TC（r= -0. 304,P〈0. 01）,E2 and LDL-C（r=- 0. 823,P〈0.01）,E2 and NT-proBNP （ r=- 0. 766, P〈0.01）. There is a positive correlation between E2 and TAS （r=0. 847,P〈0.01）, E2 and HDL-C（r=0. 887,P〈0. 01）,E2 and LVEF（r=0. 725,P〈0. 01）. Conclu- sion：Estrogen may improve endothelial function, inhibit cardiomyocyte hypertrophy, and reduce myocardia
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2015年第8期827-831,共5页
Journal of Clinical Cardiology
基金
甘肃省自然科学研究基金计划(No:1208RJZA110)
