摘要
目的 探讨不同性别原发性IgA肾病（IgAN）患者的临床表现和病理改变的差异.方法 收集2006年1月至2011年12月在中山大学附属第一医院经肾活检确诊为原发性IgAN患者的临床病理资料,按照性别分为男性组和女性组,分析肾活检时两组患者的临床表现及病理改变.结果 纳入原发性IgAN患者1512例,男女比为1∶1.16,肾活检时患者中位年龄为32（26,39）岁.与女性IgAN患者比较,男性IgAN患者临床表现为肾功能较差、蛋白尿较严重,患高血压、高三酰甘油血症、高尿酸血症比例较高;病理改变表现为肾脏节段硬化、肾小管萎缩/间质纤维化、间质炎性细胞浸润较严重.而女性IgAN患者肉眼血尿较常见,镜下血尿程度较严重.结论 不同性别原发性IgAN患者临床和病理改变存在一定差异,男性IgAN患者临床病理改变较女性严重.
Objective To explore the impact of gender on the clinicopathological features of patients with primary IgA nephropathy （IgAN）.Methods All patients with IgAN who were biopsyproven in The First Affiliated Hospital,Sun Yat-sen University from January 2006 to December 2011 were divided into two groups by gender：male group and female group.The clinical manifestations and pathological features of two groups were retrospectively investigated and compared.Results A total of 1512 primary IgAN patients were enrolled in the study,and the ratio of male to female was 1 ∶ 1.16,with a median age of 32（26,39） years old at biopsy.Compared to female patients,male patients with IgAN exhibited more severe clinical manifestations including worse renal function,greater urinary protein excretion,and more frequent occurrence of hypertension,hypertriglyceridemia and hyperuricemia.Besides,male patients had worse histological lesions,including more severe segmental sclerosis,tubular-atrophy/interstitial fibrosis and interstitial infiltration.For female patients,hematuria,including gross and microscopic hematuria,was more frequent.Conclusion Male patients with IgAN were with worse clinicopathological changes than those of female.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2015年第8期561-566,共6页
Chinese Journal of Nephrology
基金
“十二五”国家科技支撑计划（2011BAT10805）
中山大学5010项目（2007007）
广东省科技计划（20138022000031）
