摘要
目的:评价益气养阴法治疗糖尿病便秘的临床疗效与安全性。方法:计算机及手工检索相关文献,对国内外有关益气养阴法论治糖尿病便秘的临床随机对照试验(RCT)进行筛选,提取资料,评价方法学质量,并运用Rev Man 5.2软件进行Meta分析。结果:共纳入15项RCT,1274例患者,文献质量均偏低。Meta分析结果显示:以益气养阴法治疗糖尿病便秘,在提高临床有效率及远期疗效方面均优于西药对照组,且不良反应发生率低。就当前临床证据而言,以益气养阴法论治糖尿病便秘有较好的临床疗效与安全性,但鉴于研究质量普遍偏低,尚需进一步开展多中心、高质量的临床研究予以验证。
Objective ： To assess the curative effect and safety of tonifying qi and enriching Yin for diabetic constipation. Meth- ods：We searched relevant literatures both electronically and manually and RCTs related to treating diabetic constipation with the therapy of tonifying qi and enriching Yin were collected. Two reviewers screened studies, extracted data and evaluated the meth- odological quality of studies included independently. Meta - analysis was carried out by using RevMan 5.2 software. Results ： 15 RCTs were collected, a total of 1274 patients. The quality of RCTs was generally low. Meta - analysis showed that compared with the control group, the treatment group was superior in increasing effective rateand long -term efficacy. Besides, the incidence of adverse reactions was lower. Conclusion：Existing clinical evidences indicate that the therapy of tonifying qi and enriching Yin trea- ting diabetic constipation has certain curative effect and safety. A validation of the efficacy and safety needs further well - designed multicenter RCTs to achieve.
出处
《辽宁中医杂志》
CAS
北大核心
2015年第8期1380-1383,I0003,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81273740)
关键词
益气养阴
糖尿病便秘
META分析
tonifying qi and enriching Yin
diabetic constipation
Meta - analysis
