摘要
目的:为建立适合新疆维吾尔族患者的华法林个体化给药模型提供研究基础。方法:检测200例新疆维吾尔族患者中CYP2C9和VKORC1的基因型,并与世界不同种族人群基因型及等位基因频率进行比较。结果:新疆维吾尔族CYP2C9*1/*1基因型频率低于韩国、日本、美国及中国汉族,高于土耳其;*1/*2杂合突变型频率低于土耳其、瑞典、英国,高于韩国、日本及中国汉族;*1/*3杂合突变型频率高于日本、韩国、中国汉族、英国、美国;*3/*3基因频率高于上述人群(P<0.05)。新疆维吾尔族*1等位基因频率低于中国汉族、日本、韩国、美国,高于土耳其;*2等位基因高于中国汉族、日本、韩国,低于土耳其、瑞典、英国;*3等位基因高于中国汉族、日本、韩国、瑞典、英国和美国(P<0.05)。VKORC1-1639AA型频率高于美国、瑞典、英国,低于新加坡、日本、中国台湾、中国汉族;AG型频率高于新加坡、日本、中国台湾、中国汉族;GG型频率高于新加坡、日本、中国台湾、中国汉族,低于美国、瑞典、英国(P<0.05)。新疆维吾尔族A型等位基因频率低于中国汉族、中国台湾、日本、新加坡,高于美国、瑞典和英国;G型等位基因高于中国汉族、中国台湾、日本、新加坡,低于美国、瑞典、英国(P<0.05)。结论:新疆维吾尔族患者CYP2C9和VKORC1基因多态性分布与亚洲及欧美人群均存在明显差异。
OBJECTIVE：To provide basis for the establishment of warfarin individualized administration model that is suitable for Uighurian patients in Xinjiang. METHODS：The genotypes of CYP2C9 and VKORC1 in 200 Uighurian patients in xinjiang were detected and compared with the genotypes and allele frequency of different ethnic populations in world. RESULTS ： The frequency of CYP2Cg＊1/＊1 homozygous wild type in Xinjiang Uighurian patients was lower than South Korea, Japan, the United States and Han nationality in China, higher than Turkey; the frequency of ＊1/＊2 heterozygous mutant was lower than Turkey, Sweden and the United Kingdom, higher than South Korea, Japan and Han nationality in China; the frequency of ＊1/＊3 heterozygous mutant was higher than Japan, South Korea, Han nationality in China, the United Kingdom and the United States; the frequency of ＊3/＊3 was higher than the populations above（P〈0.05）. ＊1 allele in Xinjiang Uighurian patients was lower than Han nationality in China, Japan, South Korea and the United States, higher than Turkey（P〈0.05）. ＊2 allele was higher than Han nationality in China, Japan and South Korea, lower than Turkey, Sweden and the United Kingdom（P〈0.05）. ＊3 allele was higher than Han nationality in China, Japan, South Korea, Sweden, the United Kingdom and the United States（P〈0.05）. The frequency of VKORCl-1639AA in Xinjiang Uighurian patients was higher than the United States Sweden, the United Kingdom, lower than Singapore, Japan, Taiwan China and Han nationality in China. The frequency of type AG was higher than Singapore, Japan, Taiwan China, Han nationality in China. The frequency of type GG was higher than Singapore, Japan, Taiwan China, Han nationality in China, lower than the United States, Sweden and the United Kingdom（P〈0.05）. Type A allele in Xinjiang Uighurian patients was lower than Han nationality in China, Taiwan China, Japan and Singapore, higher than the United States, Sweden and the United Kingdom; type G was higher th
出处
《中国药房》
CAS
北大核心
2015年第24期3332-3334,共3页
China Pharmacy
基金
新疆医科大学第一附属医院院内科研基金项目(No.2013ZRQN21)
