摘要
目的:探讨人趋化因子受体6(CCR6)及其配体CCL20的表达与结肠癌肝转移的关系。方法:选择2012年10月-2014年10月在本院行结肠癌根治术的患者93例作为研究对象,采用实时荧光定量PCR检测93例患者的结肠癌组织、正常肠黏膜组织及其中14例结肠癌肝转移组织、肝转移灶旁肝组织中CCL20及CCR6 m RNA表达情况,分析比较其差异。结果:CCR6及CCL20 m RNA在结肠癌和肝转移灶中高表达,并且均显著高于癌旁组织,比较差异有统计学意义(P<0.05)。结肠癌组织中CCR6及CCL20 m RNA表达与患者的性别、年龄、肿瘤大小及组织学类型无明显关系(P>0.05),与TNM分期有关(P<0.05)。结论:CCR6及其配体CCL20可能参与调节结肠癌向肝脏特异性转移过程。
Objective： To investigate the relationship between CCR6, CCL20 and liver metastasis of colorectal cancer. Method： 93 patients who received radical operation for carcinoma of colon in our hospital from October 2012 to October 2014 were selected as the research objects.The expression situation of CCR6, CCL20 mRNA in 93 patients＇ colorectal cancer tissues, normal mucosa tissues and 14 patients＇ colorectal liver metastases tissues, adjacent nontumorous liver tissues was examined by real-time fluorescent quantitative PCR.The differences among them were analyzed and compared.Result： The expression of CCR6, CCL20 mRNA in colorectal cancer tissues and metastatic liver focus were significantly higher than in the adjacent tissues, the differences were statistically significant （ P〈0.05 ） .The expression of CCR6, CCL20 mRNA in colorectal cancer tissues had , no slgmficant correlation with the patients＇ sex, age, tumor size and pathological types （ P〉0.05 ）, but it had a relationship with TNM-staging （ P〈0.05 ） .Conclusion： CCR6 and CCL20 may take part in the regulation of colorectal liver metastasis.
出处
《中国医学创新》
CAS
2015年第23期49-52,共4页
Medical Innovation of China
