摘要
目的探讨莫沙必利联合铝碳酸镁治疗胆汁反流性胃炎(RBG)的临床疗效。方法收集2010年10月至2014年10月本院收治的RBG患者60例,随机分为对照组和联合治疗组,对照组给予莫沙必利治疗,联合治疗组给予莫沙必利联合铝碳酸镁治疗,分别比较患者的治疗疗效、胆汁反流情况、临床症状评分和不良反应发生状况。结果联合治疗组患者治疗有效率(93.8%)明显高于对照组(71.4%),两者差异有统计学意义(χ2=7.090;P<0.05);联合治疗组患者反流次数、>5 min的反流次数、反流总时间百分比指标值均小于对照组(t=-4.072,-8.416,-5.256;P<0.01),恶心、腹痛和腹胀的评分均低于对照组(t=-9.247,-2.833,-8.390;P<0.05),但两组最长反流时间和呕吐评分的差异无统计学意义(t=-1.872,1.767;P>0.05);联合治疗组不良反应发生率6.25%(2/32)和对照组不良反应发生率10.7%(3/28)差异无统计学意义(χ2=3.202;P>0.05)。结论莫沙必利联合碳酸铝镁既能结合胆汁反流物,又能促进胃肠动力,且不良反应发生少,适用于RBG患者的治疗。
Objective To evaluate the clinical efficacy of combined usage of mosapride and hydrotclcire for bile reflux gastritis. Methods 60 cases of RBG patients treated in our hospital from October 2010 to October 2014 were randomly divided into control group given mosapride and combined treatment group given mosapride and hydrotclcire. Such treatment results as clinical efficacy, bile reflux, clinical symptom scores and adverse reactions were compared between these two groups. Results The treatment efficiency of combined treatment group （93.8%） was significantly higher than that of the control group （71.4%）. The difference was statistically significant （χ2 =7. 090, P 〈0. 05） ; In the combined treatment group, the reflux episodes, reflux episodes （ 〉5 min） and the per- centile index of total reflux time were lower than the control group （ t = - 4. 072, - 8. 416, - 5. 256, P 〈 0.01 ）. Also the nausea scores, abdominal pain scores, and bloating scores were lower than the control group （t = - 9. 247, - 2. 833, 8. 390, P 〈 0.05 ）. However, there was no difference between the two groups in the longest reflux time and vomiting scores （t = -1. 872, 1. 767, P 〉 0. 05 ）, there was no statistically significant difference in incidence of adverse reaction （ χ2 = 3. 202, P 〉 0.05 ）. Conclusions The combination usage of mosapride and hydrotclcire can conjugate bile reflux, promote gastrointestinal motility and cause fewer adverse re- actions, and therefore it is applicable for RBG patients.
出处
《辽宁医学院学报》
CAS
2015年第4期19-21,共3页
Journal of Liaoning Medical University (LNMU) Bimonthly
