摘要
目的:分析血清脂蛋白(a)[Lp(a)]和同型半胱氨酸(Hcy)水平与中老年高血压病患者颈动脉粥样硬化的关系。方法:选择年龄45-65(57.4±7.5)岁原发性高血压病患者120例,根据颈总动脉彩色超声检查结果分为内膜-中层厚度(IMT)正常组(n=58)、IMT增厚组(n=39)、内膜斑块形成组(斑块形成组,n=23)。平行检测三组Lp(a)和Hcy水平,统计学分析组间差异及Lp(a)、Hcy水平与IMT的相关性。结果:IMT增厚组和斑块形成组Lp(a)、Hcy和IMT均高于IMT正常组(P<0.05或0.01);且斑块形成组上述指标水平又明显高于IMT增厚组,差异均有统计学意义(P<0.05)。相关性分析表明,Lp(a)、Hcy水平与颈总动脉IMT呈显著正相关(P<0.05)。结论:中老年原发性高血压病患者的Lp(a)和Hcy水平增加可能促进动脉粥样硬化。
Objective： To analysis relationship between the serum lipoprotein a [Lp（a）] and homocysteine （Hcy） levels with the degree of carotid atherosclerosis. Method： 120 cases with hypertension patients in middle-aged （45-65,57.4±7.5 years） were choosed and divided into three groups, including the intima-media thickness （IMT） normal group（n=58）, the IMT thickening group（n=39）, and the atheroma group（n=23）,which according to the degree of carotid artery atherosclerosis under carotid ultrasound examination. To parallel detecte Lp （a） and Hcy for analysis of the statistical differences between groups. Results： The levels of serum Lp （a）, Hcy of the IMT thickening group and the atheroma group were higher than IMT normal group（P〈0.05,P〈0. 001）. The levels of serum Lp （a）, Hcy of the atheroma group were higherthan IMTthickening group. The difference was statistically significant （P〈0.05）. Logistic stepwise regression analysis found that the LP （a）, Hcy were positively correlated carotid artery IMT （P〈0.05）. Conclusion： High level of serum Lp （a）, Hcy in middle-aged patients with hypertansion might promote atherosclerosis.
出处
《微循环学杂志》
2015年第3期48-50,54,共4页
Chinese Journal of Microcirculation
