摘要
马尔尼菲青霉菌是艾滋病患者常见的机会性致病菌，其致病性与自身毒力因子、致病基因及宿主免疫等有关。随着全基因组测序的完成，基于基因组学和蛋白质组学的新技术不断运用于马尔尼菲青霉菌的致病性研究中。此文就目前马尔尼菲青霉菌致病机制的研究进展进行综述。
Penicillium marneffei （P.marneffei） is a common opportunistic fungal pathogen in AIDS patients. It has been considered that the pathogenicity of this fungus is related to its virulence factors, pathogenic genes and the immune state of hosts. With the accomplishment of the whole genome sequencing of P.marneffei, new technologies based on genomics and proteomics have been applied to the research on its pathogenicity gradually. This article aims to review the recent advances on the pathogenic mechanism of Pmarneffei.
出处
《国际流行病学传染病学杂志》
CAS
2015年第4期256-259,共4页
International Journal of Epidemiology and Infectious Disease
基金
国家自然科学基金青年基金（81301480）
国家科技重大专项（2013ZX10001004）
关键词
机会致病菌感染
马尔尼菲青霉菌
致病性
毒力因子
Opportunistic infections
Penicillium marneffei
Pathogenicity
Virulence factor
