摘要
目的:比较不同重复经颅磁刺激(r TMS)模式对慢性精神分裂症阴性症状的疗效及安全性研究。方法:将90例慢性精神分裂症患者随机分为5Hz组、10Hz组、伪刺激组,每组30例。3组在维持原有抗精神病药物种类及剂量不变的基础上,刺激部位均选择左侧前额叶背外侧皮质区(DLPFC),刺激强度为80%运动阈值,每天1次,每周5次,共2周。治疗前后采用阳性与阴性症状量表(PANSS)和阴性症状量表(SANS)量表评定疗效。结果:3组治疗后比较,PANSS总分、阴性因子分、SANS评分差异有统计学意义(F=22.99,39.73,31.90;P均<0.05),10Hz组较伪刺激组PANSS总分、阴性因子分、SANS评分低,差异有统计学意义(q=-5.60,-5.70,-7.67;P均<0.05);10Hz组较5Hz组PANSS总分、阴性因子分、SANS评分低,差异有统计学意义(q=-4.97,-5.80,-7.40;P均<0.05)。与治疗前比较,10Hz组PANSS总分、阴性因子分、SANS评分降低,差异有统计学意义(t=-5.45,-7.03,-7.23;P均<0.05);5Hz组和伪刺激组PANSS总分及各因子分、SANS评分差异无统计学意义(P均>0.05)。结论:10Hz r TMS模式能改善慢性精神分裂症患者阴性症状。
Objective：To investigate the efficacy and safety of repetitive transcranial magnetive stimu-lation（ rTMS） with different protocols in treating the negative symptoms of chronic schizophrenia.Methods：Ninety patients with chronic schizophrenia who had prominent negative symptoms were randomly assigned to three treatment groups：5Hz,10 Hz,and sham rTMS.In the 5Hz and 10 Hz groups,the left dorsolateral prefrontal cortex was stimulated at 80% of the motor threshold five times per week for two weeks,while being maintained on their former antipsychotic treatment.Before and after the treatment,the Positive and Negative Syndrome Scale（ PANSS） and the Scale for the Assessment of Negative Symptoms （ SANS） were used to assess the psychotic symptoms.Results：The differences of the total scores of PANSS,the scores of negative symptoms and the total scores of SANS were statistically different after the treat-ment（F=22.99,39.73,31.90;P〈0.05）.The total scores of PANSS,the scores of negative symptoms and the total scores of SANS of 10Hz group were lower than the scores of sham rTMS group（ q=-5.60,-5.70,-7.67;P〈0.05）and the scores of 5Hz rTMS group（q=-4.97,-5.80,-7.40;P〈0.05）.The total scores of PANSS,the scores of negative symptoms and the total scores of SANS of 10Hz group were lower after the treatment than these scores before the treatment（t=-5.45,-7.03,-7.23;P〈0.05）.There was no significant difference in the total scores of PANSS,the scores of negative symptoms and the total scores of SANS between 5Hz group and sham rTMS group before and after the treatment.Conclusion：It is effective and safe to use 10 Hz rTMS to treat the negative symptoms of chronic schizophrenia.
出处
《中国健康心理学杂志》
2015年第8期1125-1128,共4页
China Journal of Health Psychology
基金
南京医科大学科技发展面上基金项目(编号:2013NJMU206)
无锡市医院管理中心医学科研项目(编号:YGZXQ1307)
关键词
重复经颅磁刺激
精神分裂症
阴性症状
安全性
Repetitive transcranial magnetic stimulation
Schizophrenia
Negative symptoms
Safety
