摘要
目的探讨腹膜透析并发感染性腹膜炎患者血清降钙素原(PCT)检测的临床意义,为腹膜透析并发感染性腹膜炎的早期发现提供参考依据。方法选取2011年3月-2013年3月医院腹膜透析中心行腹膜透析患者126例,采用电化学发光免疫分析方法检测腹膜透析相关性腹膜炎组62例、非腹膜炎组64例,同期选取健康体检人员60名为对照组,对3组受试者血清PCT水平检测,比较其C-反应蛋白(CRP)和白细胞计数(WBC)。结果腹膜炎组、非腹膜炎组和健康对照组PCT水平和阳性率分别为(5.25±1.72)(0.68±0.16)(0.51±0.13)μg/L和88.71%、4.69%、3.33%;腹膜炎组PCT水平和阳性率均明显高于非腹膜炎组和健康对照组(P<0.05);腹膜透析并发感染性腹膜炎患者治疗后血清PCT表达水平和阳性率明显下降,与治疗前比较差异有统计学意义(P<0.05)。结论血清PCT水平在腹膜透析并发感染性腹膜炎患者中明显升高,是一项良好的对腹膜透析并发感染性腹膜炎鉴别诊断和疗效监测指标。
OBJECTIVE To explore the clinical significance of serum procalcitonin （PCT ） in detection of complicated infectious peritonitis due to peritoneal dialysis so as to provide guidance for early detection of the complicated infec‐tious peritonitis due to peritoneal dialysis .METHODS A total of 126 patients who underwent the peritoneal dialy‐sis in the peritoneal dialysis center from Mar 2011 to Mar 2013 were enrolled in the study and divided into the peri‐toneal dialysis‐related peritonitis group with 62 cases and the non‐peritoneal dialysis‐related peritonitis group with 64 cases according to the results of electrochemiluminescence immunoassay ,meanwhile ,60 healthy people who re‐ceived physical examination were recruited as the control group .The level of serum PCT was determined ,the C‐reactive protein （CRP） and white blood cells （WBC） counts were compared among the three groups of partici‐pants .RESULTS The level of PCT of the peritonitis group was （5 .25 ± 1 .72）μg/L ,the non‐peritonitis group （0 .68 ± 0 .16）μg/L ,the control group （0 .51 ± 0 .13）μg/L ;the positive rate of PCT of the peritonitis group was 88 .71% ,the non‐peritonitis group 4 .69% ,the control group 3 .33% ;both the PCT level and the positive rate of the peritonitis group were significantly higher than those of the non‐peritonitis group and the control group （P〈0 .05） .The level of expression of serum PCT and positive rate of the patients with peritoneal dialysis‐related infec‐tious peritonitis were significantly reduced after the treatment ,as compared with those before the treatment （P〈0 .05） .CONCLUSION The level of serum PCT of the patients with peritoneal dialysis‐related infectious peritonitis is significently elevated ,and it is an effective indicator for differential diagnosis of the peritoneal dialysis‐related in‐fectious peritonitis and the surveillance of efficacy .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第16期3610-3612,共3页
Chinese Journal of Nosocomiology
基金
河南省卫生厅科技基金资助项目(2011010036)
关键词
腹膜透析
感染性腹膜炎
降钙素原
Peritoneal dialysis
Infectious peritonitis
Procalcitonin
