摘要
目的:评价伽玛刀联合肝动脉栓塞化疗(TACE)与单纯TACE治疗肝癌的远期疗效及安全性。方法:计算机检索国内外相关数据库,由两名评价者纳入国内外公开发表的有关伽玛刀联合TACE治疗肝癌与单纯TACE治疗肝癌的临床随机对照试验。采用Meta分析方法,在Rev Man5.1软件中统计分析相应指标。结果:纳入8项独立的临床随机对照试验研究共685名患者,Meta分析结果显示:伽玛刀联合TACE组的1、2年生存率与单纯TACE组相比有统计学差异(P<0.01)。结论:伽玛刀联合TACE治疗肝癌的远期疗效优于单纯TACE治疗。
Objective：To estimate the efficacy and safety of body gamma knife（ GK）combined with transcatheter arterial chemoembolization（ TACE）in comparison with TACE alone in the treatment of primary hepatocellular carci-noma（ PHC）. Methods：We searched the Cochrance Library,PubMed,Embase,CBM,CNKI,VIP and Wanfang（ from 2005 to 2012）for relevant studies. Two reviewers independently retrieved clinical controlled trials according to the in-clusion and exclusion criteria,assessed the methodological quality of included trials,and extracted data. Meta-analy-sis was performed by RevMen 5. 1 software. Results：Eight studies involving 685 patients were included. The results of meta-analysis showed that gamma knife combined with TCAE,compared with TACE alone,could significantly im-proved survival（P〈0. 01）,while there was no significant difference in side effect（P＆gt;0. 05）. Conclusion：The effect with body gamma knife plus TACE was better than with TACE alone in the treatment of PHC.
出处
《现代肿瘤医学》
CAS
2015年第17期2472-2475,共4页
Journal of Modern Oncology
关键词
肝癌
伽玛刀
META分析
TACE
primary hepatocellular carcinoma
body gamma knife
TACE
Meta-analysis
