摘要
目的探讨在不同类型代谢综合征（metabolicsyndrome，Ms）患者血浆中可溶性晚期糖基化终产物受体（solublereceptorforadvancedglycationendproduets，sRAGE）与动脉僵硬度的关系。方法采用病例对照的方法，选择非代谢综合征（nonmetabolicsyndrome，NMS）患者60例，非糖尿病代谢综合征（metabolicsyndromewithoutdiabetesmellitus，NDMMS）患者60例，糖尿病代谢综合征（metabolicsyndromewithdiabetesmellitus，DMMS）患者60例，对所有研究对象行相关血液生化检查，ELISA法检测研究对象血浆中sRAGE水平，用法国康普乐动脉硬化测量仪检测颈股动脉脉搏波传导速（carotid—femoralpulsewavevelocity，CFPWV）。多组间均数比较采用方差分析，组间两两比较使用LSD—t检验；sRAGE与CFPWV的相关性分析采用Pearson相关分析，采用Stepwise法进行多重线性回归对影响CFPWV的因素进行分析；以P〈0．05为差异有统计学意义。结果DMMS组和NDMMS组的sRAGE水平明显低于NMS组[（635．07±229．20）pg／mlvs．（671．17±358．16）pg／mlvs．（992．99±427．83）pg／nd，P=0．001]；DMMS组的CFPWV明显高于NDMMS组与NMS组[（14．22±3．14）m／sUS．（12．15±2．79）m／s vs．（11．66±2．52）m／s，P=0．002]。sRAGE与CFPWV呈负相关（r=-0．278，P=0．005）。多重线性回归分析显示年龄（p=-0．091，95％CI-0．096～-0．095，P=0．031）是CFPWV的危险因素，而HDL—C（B=1．295，95％CI1．231～1．360，P=0．022）和sRAGE（8=0．119，95％C10．118～0．130，P=0．032）是CFPWV的保护因素。结论随着血浆中sRAGE水平下降MS患者大动脉僵硬度增加，血浆中sRAGE水平升高可能对早期血管病变具有保护作用。
Objective investigate the correlation between plasma soluble receptor for advanced glycation endproduets （sRAGE） and arterial stiffness in patients with different types of metabolic syndrome （MS）. Methods A total of 180 subjects were drawn from a epidemiologic follow-up study, including 60 cases non-metabolic syndrome （NMS） , 60 cases metabolic syndrome without diabetes mellitus （NDMMS）, 60 cases metabolic syndrome with diabetes mellitus （DMMS）. Carotid femoral arterial pulse wave velocity （CFPWV） was assessed by the French KangPuLe atherosclerosis measurement instrument, and plasma sRAGE levels were measured by ELISA. Comparison of mean in multiple groups was conducted by analysis of variance. Multivariate analysis was done with multiple linear stepwise regression analysis. P 〈 0. 05 was considered as statistically significant difference. Results Compared with NMS group, plasma sRAGE levels were significantly lower in DMMS and NDMMS groups [ （635.07 ± 229. 20） pg/mL vs. （ 671.17 ± 358. 16 ） pg/mL vs. （992. 99 ± 427.83 ） pg/mL, P = 0. 001 ] . CFPWV of DMMS group was significantly higher than that of NMDMS and NMS groups （ 14. 22 ± 3.14） m/s vs. （ 12. 15 ± 2. 79） m/s vs. （ 11.66 ± 2. 52） m/s, P = 0. 002 ）. Plasma sRAGE level was negatively correlated with CFPWV （ r = - O. 278, P = 0. 005） . （3） Multiple linear regression analysis demonstrated that age （ 13 = -0. 091, 95% CI -0. 096 - -0.095, P= 0.031）, HDL-C （13 = 1.295,95%CI1.231-1.360, P= 0.022） andsRAGE （13 = 0. 119, 95% CI 0. 118 -- 0. 130, P = 0. 032 ） had a significant effect on CFPWV. Conclusions The increased arterial stiffness is closely related to the discreased plasma sRAGE levels in MS. Plasma sRAGE maybe a novel target for vascular disease prevention and treatment in patients with metabolic syndrome.
出处
《中华急诊医学杂志》
CAS
CSCD
北大核心
2015年第8期882-886,共5页
Chinese Journal of Emergency Medicine
基金
广州市科信局重大民生攻关专项资助项目（2012Y2-00027）
广东省科技计划项目资助项目（20128061700049）
广州市医学重点学科建设资助项目
