摘要
目的探讨颅脑外伤患者术后颅内感染的相关因素及治疗对策,为临床治疗提供参考依据。方法从医院2011年9月-2013年9月收治的颅脑外伤术后颅内感染患者中随机选择47例进行研究,设为观察组,同期选择47例颅脑外伤术后未出现颅内感染的患者作为对照组,比较患者感染因素,数据采用SPSS 15.0软件进行分析。结果经单因素分析两组患者性别、年龄、术后抗菌药物等指标比较差异均无统计学意义;但术前GCS评分、手术时间等指标比较差异均有统计学意义(P<0.05);对具有统计学意义的各项变量进行多因素分析可得,脑室外引流时间>2d、手术时间≥4h、后颅窝手术、脑脊液漏、空腹血糖>11.1mmol/L等指标为医院感染的危险因素;经针对性治疗,观察组患者痊愈的有40例,死亡7例,病死率为14.9%。结论颅脑外伤术后颅内感染受到诸多因素的影响,临床要根据患者的实际情况选择合适的治疗方案。
OBJECTIVE To explore the related risk factors for postoperative intracranial infections in the patients with craniocerebral injury and put forward the treatment countermeasures so as to provide guidance for the clinical treatment .METHODS A total of 47 craniocerebral injury patients with postoperative intracranial infections who were treated from Sep 2011 to Sep 2013 were randomly extracted as the observation group ,meanwhile ,47 cranio‐cerebral injury patients without postoperative intracranial infections were assigned as the control group .The risk factors for the infections were observed ,and the statistical analysis of data was performed with the use of SPSS 15 .0 software .RESULTS The univariate analysis showed that there was no significant difference in the genders , age ,or postoperative antibiotic between the two groups ,however ,there was significant difference in the preopera‐tive GCS score and operation duration （P〈0 .05） .The multivariate analysis of the variables with significance indi‐cated that the risk factors for the nosocomial infections included the time of external ventricular drainage more than 2 days ,operation duration no less than 4 hours ,posterior fossa surgery ,leakage of cerebrospinal fluid ,and level of fasting blood glucose more than 11 .1 mmol/L .Through the targeted treatment ,40 cases were cured in the ob‐servation group ,and 7 cases died ,with the mortality rate of 14 .9% .CONCLUSION There are a variety of risk factors for the postoperative intracranial infections in the patients with craniocerebral injury .It is necessary for the hospital to choose the appropriate therapy based on the actual situation of the patients .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第15期3501-3503,共3页
Chinese Journal of Nosocomiology
基金
山东省科技攻关基金资助项目(2010GSF10212)
关键词
颅脑外伤
手术
颅内感染
因素
治疗
Craniocerebral injury
Surgery
Intracranial infection
Factor
Treatment
