摘要
目的:探讨红霉素与阿奇霉素序贯治疗小儿肺炎支原体肺炎(MPP)中的应用效果。方法:我院2012年1月至2014年12月收治的120例肺炎支原体性肺炎患儿,采用随机数字表法分为对照组和观察组各60例,两组均给予常规治疗,对照组在常规治疗基础上给予阿奇霉素,观察组给予红霉素和阿奇霉素序贯治疗,比较两组的临床疗效、临床症状改善情况、肿瘤坏死因子(TNF-α)水平以及不良反应。结果:观察组治疗总有效率96.67%,高于对照组的83.33%,患儿平均住院时间、退热时间及止咳时间均短于对照组,治疗后血清TNF-α水平改善程度优于对照组,两组比较差异均有统计学意义(P<0.05)。两组用药期间均未发生肝肾功能损害等严重不良反应,观察组不良反应发生率10.0%,对照组不良反应发生率11.67%,均为胃肠道反应,两组比较差异无统计学意义(P>0.05)。结论:小儿肺炎支原体性肺炎治疗中应用红霉素静脉滴注与阿奇霉素口服序贯治疗比阿奇霉素静脉滴注与阿奇霉素口服序贯治疗效果更好,可有效改善患儿症状及血清TNF-α水平,值得临床推广应用。
Objective： To observe the clinical efficacy of erythromycin and azithromycin sequential therapy for infants with mycoplasma pneumoniae pneumonia. Methods： One hundred and twenty children of Mycoplasma pneumoniae pneumonia in our hospital from January 2012 to 2014 December were randomly divided into control group （60 cases） and observation group （60 cases）. The control group was treated with azithromycin and observation group was given erythromycin and azithromycin sequential therapy, then compared the clinical efficacy, the improvement of clinical symptoms, the level of tumor necrosis factor-or （TNF-ct） and adverse reaction of two groups. Results： The total effective rate of the treatment group was 96.67%, higher than that of the control group （83.33%）. The average length of hospital stay, time of fever and cough were shorter than those in the control group. After treatment, the level of serum TNF-α improved better than the control group, and the difference was significant （P〈0.05）. Conclusion： The effect of erythromycin and azithromycin sequential therapy is better than azithromycin therapy for mycoplasma pneumoniae pneumonia in infants. This therapy can effectively improve symptoms and serum TNF-ct level, is worthy of clinical reference and further observation.
出处
《儿科药学杂志》
CAS
2015年第8期20-22,共3页
Journal of Pediatric Pharmacy
关键词
儿童
肺炎支原体
肺炎
红霉素
阿奇霉素
Child
Mycoplasma pneumoniae
Pneumonia
Erythromycin
Azithromycin
