摘要
目的：探讨亚临床甲状腺功能减退症（SCH）与糖尿病肾脏疾病（DKD）的相关性。方法：入选我科住院合并DKD的2型糖尿病患者404例，根据FT3、FT4、TSH分组，甲功正常组331例。SCH组73例，比较两组临床指标及相关并发症的差异，分析SCH与DKD的相关性。结果：与甲功正常组相比，SCH组肌酐高（P〈0．001），尿素氮高（P〈0．001），肾小球滤过率（eGFR）低（P〈0．001），差异均有统计学意义；两组相比，SCH组肾功能不全[eGFR〈60mL／（min·1．73m2）]比例显著高于甲功正常组（47．95％ vs.22．96％，P〈0．001）。将eGFR作为因变量，进行多因素Logistic回归分析．SCH是DKD患者肾功能不全的独立危险因素（OR：2．015，95％CI：1．090～3．723。P=0．025）。结论：DKD合并SCH患者肾脏损害较甲功正常患者严重，发生肾功能不全风险高；SCH可能是DKD患者肾功能不全的独立危险因素。
Objective To investigate the correlation between the subclinical hypothyroidism （SCH） and the type 2 diabetes patients with diabetic kidney disease （DKD）. Methods Four hundred and four patients of type 2 diabetes with DKD were enrolled in this study. According to the levels of Thyroid-stimulating hormone （TSH）. Free Triiodothyronine （FT3）. free thyroxine （FT4）, the patients were divided into two groups as follows, the normal thyroid function group （331 cases） and the SCH group （73 cases）. By comparing the difference of clinical indicators and related complications between these two groups, the relevance between SCH and DKD was analyzed. Results The SCH group had higher serum creatinine （P 〈 0.001） and blood urea nitrogen （P 〈 0.001）, lower proportion of estimated glomerular filtration rate （P 〈 0.001） than those in the normal thyroid function group. The proportion of renal insufficiency [eGFR 〈 60 mL/（min· 1.73 m2） ] in the SCH group was significantly higher than that in the normal thyroid function group （47.95% vs. 22.96%, P 〈 0.001 ）. eGFR was used as a dependent variable for the logistic regression analysis, SCH was the independent risk factor for renal insufficiency in patients with DKD （OR： 2.015, 95%CI： 1.090-3.723, P= 0.025）. Conclusion The patients with both DKD and SCH have worse renal impairment than the patients with normal thyroid function, and have higher risk in renal insufficiency; SCH may be an independent risk factor for renal insufficiency in patients with DKD.
出处
《实用医学杂志》
CAS
北大核心
2015年第16期2623-2625,共3页
The Journal of Practical Medicine
基金
国家自然科学基金(编号:81141059)
河南省卫生科技创新型人才工程
洛阳市科技发展计划(编号:1002239B)
