摘要
目的探讨肥胖患者应用顺苯磺酸阿曲库铵的肌松效应。方法选取该院收治的行全身气管插管静脉麻醉择期手术患者90例作为研究对象,按照患者体质量分为A组(正常体质量组)、B组和C组(肥胖组,C组体质量略高于B组)。3组均给予顺苯磺酸阿曲库铵麻醉诱导并采用肌松监测仪进行拇内收肌肌松监测,T1/Tc不足10%时给予气管插管,A组和B组按照患者实际体质量给药,C组按照理想体质量给药,比较3组患者的恢复指数、起效时间、作用时间以及气管插管条件评级等。结果 B组药物作用时间延长,药物起效时间缩短,C组药物作用时间缩短,药物起效时间延长,差异有统计学意义(P<0.05)。结论按实际体质量给肥胖患者应用顺苯磺酸阿曲库铵肌松效果良好,起效时间短,作用时间长,改善患者耐受性,具有积极的临床使用和推广价值。
Objective To study and analyze the muscle relaxation effect of cisatracurium besilate in obese pa‐tients .Methods 90 patients undergoing elective operation under endotracheal intubation intravenous general anesthe‐sia in our hospital were selected as the research subjects and according to the body mass index were divided into the group A（normal body weight group） ,B and C（obesity groups ,the body weight in the group C was slightly higher than that in the group B） .The three groups were given cisatracurium besylate for anesthesia induction and the muscle relaxation monitor was adopted to conduct the adductor pollicis muscle relaxation monitoring ,when T1/Tc was less than 10% ,the tracheal intubation was given .The group A and B were given the medication according to the actual body mass ,while the group C was given the medication according to the ideal body mass .The recovery index ,onset time ,acting time ,tracheal intubation condition rating ,etc .were compared among 3 groups .Results The drug action time in the group B was prolonged and the drug onset time was shortened ,while the drug action time in the group C was shortened and the drug onset time was prolonged ,the differences were statistically significant（P〈0 .05） .Conclu‐sion Using cisatracurium besylate according to the actual body mass in obese patients has good muscle relaxation effect with short onset time and long action time ,improves the patient tolerance and has positive clinical use and pop‐ularization value .
出处
《检验医学与临床》
CAS
2015年第15期2178-2179,共2页
Laboratory Medicine and Clinic
关键词
顺苯磺酸阿曲库铵
肌松效应
肥胖患者
cisatracurium besylate
muscle relaxation effect
obese patients
