摘要
目的了解急性心肌梗死患者血清中1,25-二羟基维生素D3[(1,25(OH)2D3]的水平及与血清中高敏C反应蛋白(hs-CRP)、基质金属蛋白酶9(MMP-9)的关系。方法选取2009年7月至2010年7月就诊于内蒙古科技大学包头医学院第一附属医院老年病科的急性心肌梗死患者60例作为病例组,同期健康体检者60例作为对照组,测定所有纳入者血清中的1,25(OH)2D3、hs-CRP和MMP-9水平。结果病例组1,25(OH)2D3水平显著低于对照组,而hs-CRP和MMP-9水平显著高于对照组,差异有统计学意义(P<0.01)。病例组中1,25(OH)2D3水平与hs-CRP及MMP-9呈负相关(r=-0.679,-0.597,P<0.01),而hs-CRP与MMP-9呈正相关(r=2.781,P<0.05)。结论急性心肌梗死患者血清1,25(OH)2D3、hs-CRP和MMP-9与健康对照组之间存在差异,这种变化可能与急性心肌梗死患者血管的炎性变化有关。
Objective To investigate the serum level of 1,25-dihydroxy vitamin D3[1,25（OH）2D3] in patients with acute myocardial infarction and its relationship with high-sensitivity C-reactive protein （hs-CRP）and matrix metalloproteinases-9（MMP-9）.Methods A total of 60 patients with acute myocardial infarction treated in the First Hospital of Baotou Medical College,Inner Mongolia University of Technology from Jul.2009 to Jul.2010 were chosen as the patient group,and 60 healthy persons during the same period were included as control group.The serum levels of 1,25（OH）2D3,hs-CRP and MMP-9 in all selected can-didates were detected.Results The levels of 1,25（OH）2D3 in the patient group were significantly lower than the control group, while the levels of hs-CRP and MMP-9 were significantly higher than the control group,the difference were statistically significant （ P 〈0.01 ） .The results showed that the serum levels of 1,25（OH）2D3 and the levels of hs-CRP,MMP-9 were significantly negatively correlated in patients group （r=-0.679,r=-0.597,P〈0.01）,while hs-CRP and MMP-9 were positively correlated（r=2.781,P〈0.05）.Conclusion The serum level of 1,25（OH）2D3,hs-CRP and MMP-9 are different in patients of acute myocardial infarction from the healthy population, which might be closely related with inflammatory changes in blood vessels of the patients.
出处
《医学综述》
2015年第14期2654-2656,共3页
Medical Recapitulate
