摘要
目的探讨儿童T2DM合并高尿酸血症(HUA)与IR、脂代谢异常的关系。方法选取T2DM患儿135例,根据血尿酸(SUA)水平分为T2DM合并HUA组(T2DM+HUA)31例和单纯T2DM组(T2DM)104例,比较两组的临床资料,分析SUA水平与糖、脂参数的关系。结果 (1)T2DM患儿中,HUA的患病率为23.0%。(2)两组年龄、病程、SBP、DBP、Scr和24hUAlb比较,差异无统计学意义(P均>0.05),T2DM+HUA组BMI[(24.55±4.19)vs(29.12±6.17)kg/m2]、黑色棘皮病发生率[22(70.97%)vs 38(36.54%)]及非酒精性脂肪性肝病(NAFLD)发生率[23(71.19%)vs 50(48.08%)]均高于T2DM组(P=0.000、0.001、0.01)。(3)T2DM+HUA组FPG、2hPG、FIns、FC-P、SUA及TG均高于T2DM组(P=0.003、0.019、0.002、0.000、0.000、0.001)。但HbA1c、胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)、Scr、24hUAlb、TC、HDL-C和LDL-C比较,差异无统计学意义(P>0.05)。(4)通过2周胰岛素降糖和低嘌呤饮食治疗后,T2DM+HUA组SUA水平较治疗前下降(P=0.001),而其他糖、脂代谢参数虽比治疗前好转,但差异无统计学意义(P>0.05)。结论与单纯T2DM患儿相比,伴HUA的T2DM患儿IR、血脂异常更显著,发生NAFLD和黑色棘皮病概率更高;T2DM患儿治疗后SUA降低。
Objective To investigate the relationship of T2DM with hyperuricemia in children with insulin resistance and lipid metabolism disorders. Methods A total of 135 children of type 2 diabetes mellitus were selected and divided into two groups：T2DM ＋ HUA group （n= 31） and T2DM group（n=104）. The relationship of uric acid level with clinical parameters of glycometabolism and lipid metabolism was evaluated. Results （1）The prevalence of hyperuricemia（HUA） in children with T2DM was 23.0%. （2） There was no significant difference in age ,duration of disease ,systolic and diastolic blood pressure ,serum creatinine and 24 hours urinary protein quantitative between the two groups（P〉0.05）. BMI[（24.55 ± 4.19） vs （29.12 ± 6.17）kg/m2 ] ,the incidence of nigricans acanthosis[22（70.97% ） vs 38 （36.54% ）] and non‐alcoholic fatty liver disease [23（71.19% ） vs 50（48.08% ）] were significantly higher in T2DM＋ HUA group than in T2DM group （P= 0.000 ,0.001 ,0.01 ,respectively）. （3） FPG ,2 hPG , FIns ,FC‐P、SUA and TG were significantly higher in T2DM ＋ HUA group than in T2DM group （P=0.003 ,0.019 ,0.002 ,0.000 ,0.000 ,0.001 ,respectively）. However ,HbA1c ,HOMA‐IR ,HOMA‐β,Scr ,24hUAlb ,TC ,LDL‐C and HDL‐C were similar in both groups （P〉0.05）. （4） The uric acid levels in T2DM＋ HUA group were significantly decreased after 2 weeks treatment of insulin and low purine diet（P=0.001）. But the other glucose and lipid metabolism disorders were not significantly improved（P〉0.05） . Conclusion Children T2DM with HUA have higher insulin resistance and dyslipidemia. The incidence of nigricans acanthosis and non‐alcoholic fatty liver disease were significantly higher in T2DM＋ HUA group than in T2DM group. SUA is decreased after treatment of children T2DM.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2015年第8期726-729,共4页
Chinese Journal of Diabetes
