摘要
目的探讨甘草酸二铵肠溶胶囊治疗慢性病毒性肝炎的临床疗效。方法将收治的慢性病毒性肝炎患者100例,随机分为对照组和治疗组,各50例。对照组给予α-2b干扰素治疗,每次3 000万U,每周3次;治疗组在对照组基础上加用甘草酸二铵肠溶胶囊150 mg,3次/日。两组疗程均为12周。结果治疗组治疗后总有效率为92.00%,显著高于对照组的80.00%(P<0.05);两组总胆红素、丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)治疗后较治疗前显著降低(P<0.05);治疗组总胆红素、ALT及AST治疗后显著低于对照组(P<0.05),治疗组ALT复常率和丙型肝炎病毒(HCV)-RNA转阴率显著高于对照组(P<0.05);两组在治疗中不良反应发生情况相似,且未出现严重的不良反应,不影响治疗。结论加用甘草酸二铵肠溶胶囊治疗慢性病毒性肝炎临床疗效显著,安全、可靠,具有重要的临床研究价值,值得进一步推广。
Objective To investigate the diammonium glycyrrhizinate phosphatidylcholine complex enteric - coated capsules combined α -interferon clinical efficacy of treatment of chronic viral hepatitis. Methods 100 cases of chronic viral hepatitis who received treatment in our hospital were randomly divided into two groups, each of them were 50 cases, the control group received only interferon α - 2b therapy, 30 million IU / times, three times a week. The treatment group received the diammonium glycyrrhizinate phosphatidylcholine complex enteric - coated capsules combined α - interferon treatment, 150 mg, three times / d, The treatment lasted 12 weeks. Results The overall response rate （ 92. 00% ） was significantly higher （ 80. 00% ） after treatment, and has a statistically significant difference （ P〈 0. 05）; compared the two groups after treatment total bilirubin, ALT, AST treatment significantly lower than before, and are statisti-cally different （ P〈 0. 05）; after treatment group total bilirubin, ALT, AST treatment was significantly lower than the control group, and has a statistically significant difference （ P〈 0. 05 ）; treatment group ALT normalization and HCV - RNA negative rate was significantly higher, and has a statistically significant difference （ P〈 0. 05）; similar to the control and treatment of adverse reactions occurred in the treatment of cases, and no serious adverse reactions, does not affect the treatment. Conclusion The new formulation of diammonium glycyrrhizinate phosphatidylcholine complex enteric - coated capsules combined α - interferon treatment of chronic viral hepatitis clinically significant effect, safe and reliable, has important clinical research value, worthy of further application.
出处
《中国药业》
CAS
2015年第15期108-109,共2页
China Pharmaceuticals
关键词
甘草酸二铵肠溶胶囊
慢性病毒性肝炎
临床疗效
diammonium glycyrrhizinate phosphatidylcholine complex enteric - coated capsules
chronic viral hepatitis
clinical efficacy
