摘要
目的探讨艾司洛尔对老年患者颅脑手术拔管期对心率、血压的影响。方法选取行颅脑手术的患者64例,随机分为2组（n=32）。对照组以100 m L生理盐水加硝酸甘油注射液10 mg静脉滴注,研究组则静脉缓慢静推盐酸艾司洛尔注射液1.0~1.5 mg/kg,比较2种药物对老年患者颅脑手术拔管期对心率、血压的影响。结果研究组患者在拔管前2 min、拔管期及拔管后5 min的SBP、DBP、HR与本组拔管前比较,差异无统计学意义;对照组患者在拔管前2 min的SBP、DBP、HR与本组拔管前比较,差异有统计学意义（t=5.42、4.15、5.31,P〈0.05）。结论对于接受颅脑手术的老年患者使用小剂量艾司洛尔可有效地抑制拔管期血压升高、心率增快,有助于减轻气管插管和手术刺激引起的血流动力学波动,避免增加心肌耗氧、加重心肌负担、诱发心脑血管意外。
Objective To investigate the effect of esmolol on heart rate, blood pressure during the period of elderly patients with craniocerebral operation extubation. Methods From January 2013 to December 2013, 64 cases of elective surgery patients before 10 min patients were randomLy divided into study group and control group in our hospital accepted craniocerebral operation, the control group with 100 mL normal saline plus Nitroglycerin Injection intravenous infusion of 10 rag, while the study group is slow intravenous static push Esmolol Hydrochloride Injection 1 - 1.5 mg/kg, the comparison of two kinds of drug effects on heart rate, blood pressure pipe period for elderly patients with craniocerebral operation pull. Results Patients in the study group before extubation 2 min, extubation and 5 min after extubation SBP, DBP, HR compared with the group without significant difference before extubation. While the control group patients in before extubation 2 min SBP, DBP, HR compared with the group before extubation has significant difference （t=5.42,4.15,5.31,P〈0.05）.Conolusion The use of small doses of esmolol can effectively restrain the decannulation period of elevated blood pressure, heart rate increased in older patients undergoing craniocerebral operation, help to alleviate tracheal intubation and hemodynamic fluctuations caused by the stimulation of operation, to avoid increasing myocardial oxygen consumption,the aggravation of myocardial burden, induced cardiovascular and cerebrovascular accident.
出处
《当代医学》
2015年第23期112-113,共2页
Contemporary Medicine
关键词
艾司洛尔
老年
颅脑手术
拔管期
心率
血压
Esmolol
Aged
Brain Operation
Extubation
Heart rate
Blood pressure
