摘要
目的探讨动态血糖监测系统(CGMS)联合胰岛素泵持续皮下胰岛素输注(CSII)治疗对2型糖尿病患者生活质量的影响。方法选取2011年2月至2013年2月北京军区总医院收治的新诊断2型糖尿病患者126例,依据随机数字表法分为3组,各42例。A组给予CGMS联合CSII治疗,B组给予指血血糖监测联合CSII治疗,C组给予指血血糖监测联合胰岛素多次皮下注射治疗。比较3组患者的各血糖参数,采用SF-36简式健康状况调查表(SF-36)及修订版糖尿病生活质量量表(A-DQOL)评价患者的生活质量。结果强化治疗后A、B、C组患者的空腹血糖[(6.8±1.1)mmol/L、(7.3±1.4)mmol/L、(7.1±1.7)mmol/L],餐后2 h血糖[(8.4±1.0)mmol/L、(9.4±1.3)mmol/L、(9.5±2.3)mmol/L]均较治疗前[(10.9±1.8)mmol/L、(10.6±2.3)mmol/L、(11.0±1.8)mmol/L;(15.0±2.8)mmol/L、(14.9±2.5)mmol/L、(15.3±2.4)mmol/L]明显下降(P<0.01);而平均血糖漂移度(MAGE)水平只有A组在治疗后较治疗前下降[(3.3±1.1)mmol/L比(5.3±1.5)mmol/L](P<0.05);随访结果表明,各组低血糖事件的发生次数、糖化血红蛋白和MAGE水平及SF-36量表各维度的评分值差异均有统计学意义(P<0.01);A-DQOL量表项目满意度,糖尿病相关忧虑维度和总体生活质量评分值差异均有统计学意义(P<0.05)。结论 CGMS联合胰岛素泵强化治疗能更好地改善2型糖尿病患者的总体生活质量。
Objective To investigate the effects of continuous glucose monitoring system（CGMS） com- bined with continuous subcutaneous insulin injection（CSII） on life quality in patients with type 2 diabetes mellitus. Methods A total of 126 patients with newly diagnosed type 2 diabetes mellitus hospitalized in General Hospital of Beijing Military Region from Feb. 2011 to Feb. 2013 were selected, and randomly divided into three groups ,42 cases in each group. Group A was treated with CGMS combined with CSII therapy, group B was given finger-tip blood glucose monitoring with CSII, group C was given finger-tip blood glucose monitoring with multiple daily subcutaneous injection. The blood parameters of the three groups were compared. The Medical Outcomes-36 Item Short Form Health Survey （ SF-36 ） and Adjusted Diabetes Quality of Life （A-DQOL） were used to survey the life quality of the patients. Results After intensive treatment, fasting plasma glucose [ （ 6.8±1.1 ） mmol/L, （7.3±1.4 ） mmol/L, （ 7. 1±1.7 ） mmol/L ] and 2 h plasma glucose [ （8.4±1. 0） retool/L, （9. 4±1.3 ） mmol/L, （9.5±2. 3 ） mmol/L ] levels of the group A, B, C, decreased significantly than before treatment [ （ 10. 9 ±1.8 ） mmol/L, （ 10. 6±2. 3 ） mmol/L, （ 11.0±1.8 ） retool/L;（15.0±2.8） namol/L,（14.9±2.5） mmol/L,（15.3±2.4） mmol/L] （P〈0.01）.Themean amplitude of glycemic excursions （MAGE） level of group A was lower after treatment than before treatment [ （ 3.3±1.1 ） mmol/L vs （5.3±1.5 ） mmol/L ] （ P 〈0. 05 ） ;The followed-up results showed that hypogly- cemia,HbAlc ,MAGE level and SF-36 scale scores in every dimensions of all the groups were significantly different（ P 〈0. 01 ）. The A-DQOL scale satisfaction,diabetes related anxiety dimensions and overall quality of life scores were significantly different（ P 〈 0.05 ）. Conclusion CGMS combined with CSII can effectively improve the overall life quality of patients with type 2 diabetes mellitus.
出处
《医学综述》
2015年第15期2817-2820,共4页
Medical Recapitulate
基金
军队十一五课题(06MA067)
关键词
糖尿病
动态血糖监测系统
胰岛素泵
Diabetes mellitus
Continuous glucose monitoring system
Insulin pump
