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EGFR和mTOR特异性标记与肿瘤治疗关系现状 被引量:2

Current Relationship between the Specific Markers of EGFR,mTOR and Oncotherapy
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摘要 在全球范围内,肿瘤的致死率仍然居高不下,如何加强肿瘤治疗及改善患者的生存质量仍是目前关注的焦点和亟需解决的问题。分子靶向治疗是一种针对性较强、不良反应较小的新型治疗手段,目前在多种肿瘤治疗中对于应用分子靶向治疗的研究不断增多。表皮生长因子受体及哺乳动物雷帕霉素靶蛋白是目前应用较为广泛的两种生物标志物,在肿瘤靶向治疗过程中无论独立或联合应用均具有较高的临床价值。 Worldwide, tumor mortality rates remain high , and how to strengthen the oncotherpay and improve the life quality of the patients remains a concern and urgent problem .Molecular targeted therapy is a new-type treatment that has better specificity but less adverse effect .In current research,in a variety of tumors the application of molecular targeted therapy is increasing.Epidermal growth factor receptor and mammalian target of rapamycin,which have been widely used,showed their clinical value of application in tumor-targeted therapy in both independent and combined ways.
出处 《医学综述》 2015年第15期2729-2732,共4页 Medical Recapitulate
关键词 表皮生长因子受体 哺乳动物雷帕霉素蛋白 靶向治疗 Epidermal growth factor receptor Mammalian target of rapamycin Targeted therapy
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  • 1Nogueira-Rodrigues A,do Carmo CC,Viegas C,et al.PhaseⅠTrial of erlotinib combined with cisplatin and radiotherapy for patients with locally advanced cervical squamous cell cancer[J].Clin Cancer Res,2008,14(19):6324-6329. 被引量:1
  • 2Nogueira-Rodrigues A,Moralez G,Grazziotin R,et al.Phase 2 trial of erlotinib combined with cisplatin and radiotherapy in patients with locally advanced cervical cancer[J].Cancer,2014,120(8):1187-1193. 被引量:1
  • 3Deberne M,Levy A,Mondini M,et al.The combination of the antiviral agent cidofovir and anti-EGFR antibody cetuximab exerts an antiproliferative effect on HPV-positive cervical cancer cell lines'in-vitro and in-vivo xenografts[J].Anti-Cancer Drugs,2013,24(6):599-608. 被引量:1
  • 4Bonner JA,Harari PM,Giralt J,et al.Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck[J].N Engl J Med,2006,354(6):567-579. 被引量:1
  • 5Bonner JA,Harari PM,Giralt J,et al.Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer:5-year survival data from a phase 3 randomised trial,and relation between cetuximab-induced rash and survival[J].Lancet Oncol,2010,11(1):21-28. 被引量:1
  • 6Rodríguez MO,Rivero TC,Bahi RC,et al.Nimotuzumab plus radiotherapy for unresectable squamous-cell carcinoma of the head and neck[J].Cancer Biology Ther,2010,9(5):343-349. 被引量:1
  • 7Saloura V,Cohen EE,Licitra L,et al.An open-label single-arm,phaseⅡtrial of zalutumumab,a human monoclonal anti-EGFR antibody,in patients with platinum-refractory squamous cell carcinoma of the head and neck[J].Cancer Chemother Pharmacol,2014,73(6):1227-1239. 被引量:1
  • 8Argiris A,Kotsakis AP,Hoang T,et al.Cetuximab and bevacizumab:preclinical data and phaseⅡtrial in recurrent or metastatic squamous cell carcinoma of the head and neck[J].Ann Oncol,2013,24(1):220-225. 被引量:1
  • 9Liang J,E M,Wu G,et al.Nimotuzumab combined with radiotherapy for esophageal cancer:preliminary study of a PhaseⅡclinical trial[J].Onco Targets Ther,2013,6:1589-1596. 被引量:1
  • 10Zhao L,He LR,Xi M,et al.Nimotuzumab promotes radiosensitivity of EGFR overexpression esophageal squamous cell carcinoma cells by upregulating IGFBP-3[J].J Transl Med,2012,10:249. 被引量:1

二级参考文献20

  • 1FERLA YJ, SHIN HR, BRAY F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008[J]. IntJ Cancer, 2010, 127: 2893-2917. 被引量:1
  • 2JEMAL A, BRAY F, CENTER MM, et al. Global cancer statis?tics[J]. CA CancerJ Clin, 2011, 61: 69-90. 被引量:1
  • 3KANG S, DONG SM, KIM BR, et al. Thioridazine induces apoptosis by targeting the PBKlAktimTOR pathway in cervical and endometrial cancer cells[J]. Apoptosis, 2012, 17: 989-997. 被引量:1
  • 4OSMAN A. MicroRNAs in health and disease-c-basic science and clinical applications[J]. Clin Lab, 2012, 58: 393-402. 被引量:1
  • 5HUDSON RS, YI M, ESPOSITO D, et al. MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer[J]. Oncogene, 2013, 32(35): 4139-4147. 被引量:1
  • 6FANG R, XIAO T, FANG Z, et al.: MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene[J].J Bioi Chern, 2012, 287: 23227-23235. 被引量:1
  • 7F ASOLO A, SESSA C. Targeting mTOR pathways in human ma?lignancies[J]. Curr Pharm Des, 2012, 18: 2766-2777. 被引量:1
  • 8SHEPPARD K, KINROSS KM, SOLOMON B, et al. Targeting PI3 kinase/AKT/mTOR signaling in cancer[J]. Crit Rev Oncog, 2012, 17: 69-95. 被引量:1
  • 9VANDER HEIDEN MG, CANTLEY LC, THOMPSON CB. Un?derstanding the Warburg effect: the metabolic requirements of cell proliferation[J]. Science, 2009, 324: 1029-1033. 被引量:1
  • 10AMBROS V. The functions of animal microRNAs[J]. Nature, 2004, 431: 350-355. 被引量:1

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