摘要
目的观察水蛭对经皮冠状动脉介入治疗(PCI)后支架内再狭窄(ISR)率和血小板功能的影响。方法将120例冠心病心绞痛心血瘀阻证患者随机分为治疗组和对照组各60例。2组患者随访观察12个月后复查冠状动脉造影或冠状动脉血管成像(CTA),并于术前和术后12个月检测患者血小板最大聚集率、血小板α-颗粒膜蛋白(GMP-140)、血小板因子4(PF4)和D-二聚体(D-dimmer)水平。结果治疗组ISR发生率8%,对照组为13%,治疗组ISR发生率呈下降趋势;2组血小板最大聚集率、GMP-140、PF4和D-dimmer差异有统计学意义(P<0.05)。结论水蛭可降低血小板最大聚集率、GMP-140、PF4和D-dimmer,对PCI后ISR有一定防治作用。
Objective To observe the effect of leech on coronary stent restenosis（ ISR） and platelet function after percutaneous coronary intervention（ PCI）. Methods A total of 120 patients with angina pectoris who fell into the category of syndrome of heart blood stagnation were randomly divided into the treatment group and the control group of 60 in each group. The coronary angiography or computed tomography coronary angiography（ CTA） were reexamined in both groups after follow-up for twelve months. The levels of maximum platelet aggregation rate,GMP-140,PF4,D-dimmer were tested before PCI and after PCI for twelve months. Results The ISR rate of treatment group was 8%,and that of control group 13%,the ISR rate of treatment group was declined. The difference in levels of maximum platelet aggregation rate,GMP-140,PF4,D-dimmer between the two groups had statistical significance（ P〈0. 05）. Conclusion Leech can decrease the levels of maximum platelet aggregation rate,GMP-140,PF4,D-dimmer and prevent coronary stent restenosis（ ISR） after percutaneous coronary intervention（ PCI） in a certain degree.
出处
《北京中医药》
2015年第7期540-542,共3页
Beijing Journal of Traditional Chinese Medicine
基金
河北省中医药管理局2012年度中医药类科研计划项目(2012009)
