摘要
目的:观察鱼腥草滴眼液联合奥洛他定滴眼液治疗过敏性结膜炎的临床疗效和不良反应。方法:选取过敏性结膜炎患者160例眼,按照随机数字表法分为对照组和观察组,各80例眼。对照组予以奥洛他定滴眼液进行治疗,观察组在对照组的基础上加用鱼腥草滴眼液(两药间隔时间>10 min)。两组均连续治疗14d。分别于治疗前、治疗后14d随访观察两组患者的症状体征并进行评分,计算两组患者临床有效率,并观察不良反应发生情况。结果:与治疗前比较,两组患者的症状评分和体征评分均有所下降,差异有统计学意义(P<0.01或P<0.05),且观察组的症状评分和体征评分较对照组下降更多,组间比较差异有统计学意义(P<0.01);对照组和观察组治疗后的有效率分别为37.50%和77.50%,组间比较差异有统计学意义(P<0.05)。结论:鱼腥草滴眼液联合奥洛他定滴眼液可明显改善过敏性结膜炎患者的临床症状与体征,显著提高疗效,且未出现明显不良反应。
OBJECTIVE：To observe clinical efficacy and ADR of Houttuynia cordata eye drops combined with Olopatadine eye drops in the treatment of allergic conjunctivitis. METHODS：160 eyes with allergic conjunctivitis were randomly divided into observation group and control group,with 80 eyes in each group. The control group was given olopatadine eye drops,and observation group was additionally given H. cordata eye drops（medication interval〉10 min）on the basis of control group. Both groups were treated for 14 days. Symptoms and signs of 2 groups were observed and scored before treatment and 14 d after treatment. Effective rates of 2 groups were calculated,and the occurrance of ADR was observed. RESULTS：Compared with before treatment,symptoms and sings score of 2 groups were decreased,with statistical significance（P〈0.01 or P〈0.05）;the decrease of two score in observation group were more significant than in control group,with statistical significance（P〈0.05）;effective rates of control group and observation group were 37.50% and 77.50%,with statistical significance（P〈0.05）. CONCLUSIONS：H. cordata eye drops combined with olopatadine eye drops can ameliorate clinical symptoms and signs of allergic conjunctivitis patients significantly,and improve therapeutic efficacies without obvious ADR.
出处
《中国药房》
CAS
北大核心
2015年第23期3261-3263,共3页
China Pharmacy
关键词
鱼腥草滴眼液
奥洛他定滴眼液
过敏性结膜炎
联合用药
Houttuynia cordata eye drops
Olopatadine eye drops
Allergic conjunctivitis
Drug combination
