摘要
目的 探讨克拉霉素辅助治疗儿童幽门螺杆菌阳性慢性胃炎的临床疗效。方法 选取2011年3月~2013年11月我院收治的58例幽门螺杆菌阳性的慢性胃炎患儿作为研究对象,采用随机数字表法将所选患儿分为研究组和对照组,各29例,研究组给予克拉霉素联合奥美拉唑治疗,对照组单独使用奥美拉唑治疗,随访1年,综合比较两组患儿治疗总有效率、幽门螺杆菌根除率、复发率和不良反应发生率。结果研究组治疗总有效率、幽门螺杆菌根除率分别为89.66%、93.10%,均高于对照组的65.52%、79.31%（P〈0.05）;随访1年,研究组复发率低于对照组（P〈0.05）;两组患儿不良反应发生率比较差异无统计学意义（P〉0.05）。结论 克拉霉素联合奥美拉唑治疗幽门螺杆菌阳性的慢性胃炎患儿效果确切,可明显改善临床症状,降低复发率,患儿耐受性好,值得临床推广使用。
Objective To explore the clinical efficacy of clarithromycin adjuvant therapy for the treatment of children＇s positive helicobacter pylori chronic gastritis. Methods 58 children patients with positive helicobacter pylori chronic gastritis treated in our hospital during Mar, 2011 to Nov, 2013 were chosen as study objects and divided into research group and control group and 29 patients in each group. Patients in the research group were treated with clarithromycin combined with omeprazole, and patients in the control group were treated with omeprazole only. All the patients were followed up for one year. The total effective rate, Hp elimination rate, recurrence rate and the adverse effect rate of children patients in the two groups were comprehensively compared. Results The total effective rate and Hp elimination rate of the research group were 89.66% and 93.10% respectively, higher than that of 65.52% and 79.31% in the control group （P 〈 0.05）. For one year follow-up, the recurrence rate of the research group was lower than that of the control group （P 〈 0.05）. The difference between the adverse effect rates of the two groups has no statistical significance （P 〉 0.05）. Conclusion The combined use of elarithromycin and omeprazole in the treatment of children＇s positive helicobacter pylori chronic gastritis is effective and can remarkably improve clinical symptoms, reduce recurrence rate, to which children have good tolerance. The combined use mentioned above is worthy for clinical wide application.
出处
《中国医药科学》
2015年第13期98-100,共3页
China Medicine And Pharmacy
关键词
克拉霉素
奥美拉唑
儿童慢性胃炎
幽门螺杆菌阳性
Clarithromyein
Omeprazole
Children chronic gastritis
Positive helicobacter pylori
