摘要
目的探讨紫外光-核黄素角膜交联术对进展期圆锥角膜的临床疗效及安全性。方法对22眼进行紫外光-核黄素角膜交联术,观察术后1、3、7d角膜反应,术后1、3、6个月角膜情况,角膜曲率,眼压。第6个月时测量角膜滞后量(CH)和角膜阻力因子量(CRF)与术前对比。结果术后1、3、7d,1个月角膜基质有不同程度水肿,角膜基质神经丛减少,术后3个月水肿消退,神经丛数量逐渐恢复,术后6个月角膜透明,神经丛数量恢复到术前水平。手术前后角膜强度CH值和CRF值比较具有统计学意义(P<0.01),术前术后角膜曲率变化不明显,眼压平稳,无异常波动,视力术前较术后6个月平均提高一行。结论紫外光-核黄素角膜交联术是一种有效而安全的治疗方法,使进展期圆锥角膜病程发展停止,病情趋于稳定。
Objective To investigate clinical efficacy and security of ultroviolet A/riboflavin corneal collagen crosslinking to progressive keratoconus. Methods Twenty-two eyes with progressive keratoeonus were treated by Ultraviolet A/riboflavin corneal collagen crosslinking. To observe the reaction of cornea at postoperative first, third and 7th day, and follow-up 1-6 months, containing corneal conditions, corneal curvature and intraocular pressure. At postoperative 6 month corneal hysteresis and corneal resistance factor was compared with preoperations. Results There were varying degrees of corneal edema at post-operative 1 day, 3 day, 7 day and 1month. Nerve plexus of corneal stroma decreased. Corneal edema was fading and the number of nerve plexus was restoring gradually at postoperative 3 months. The corneas were clear and the number of nerve plexus returned to the preoperative level. There was statistically significant in comparing corneal hysteresis and corneal resistance factor in pre-operation and post-operation（P 〈 0.01）. The change of corneal curvature was unobvious. The intraocular pressure was stable and without unusual changes. The vision improved a line than pre-operation. Conclusion Ultraviolet A/riboflavin corneal collagen cross linking is a secure and effective therapy and stop the development of progressive keratoconus with stable disease.
出处
《中国医药科学》
2015年第12期20-23,共4页
China Medicine And Pharmacy
关键词
紫外光-核黄素角膜交联术
圆锥角膜
角膜强度
Ultraviolet A/riboflavin corneal collagen crosslinking
Keratoconus
Cornea intensity
