摘要
革兰阴性菌细胞外膜成分脂多糖对于维持细菌的结构完整性非常重要。脂多糖被称为内毒素,是革兰阴性菌致病的物质基础。脂多糖由三部分组成,包括O-特异多糖、核心多糖和类脂A,类脂A是脂多糖的毒性中心。脂多糖可导致机体发生严重感染,引起局部或全身性病理生理反应。脂多糖的毒性作用是通过其介导的信号途径导致机体产生强烈免疫应答引起的。目前,对于脂多糖信号通路中的相关蛋白及受体的研究已取得了一定的进展。本文综述了脂多糖及其所介导信号通路中主要相关蛋白及受体的研究现状。
Lipopolysaccharide （LPS）, the important component of the outer membrane of Gram-negative bacteria, contributes to the integrity of the outer membrane, and protects the cell against bactericidal agents. LPS, also called endotoxin synonymously, is well known as a potent inducer of the innate immune system that often causes septic shock in the intensive cares. Chemically, the amphiphilic LPS is made up of three parts, i.e. hydrophobic lipid A, hydrophilic core oligosaccharide chain, and hydrophilic O-antigenic polysaccharide side chain. Specially, the lipid A is known to be responsible for a variety of biological effects during Gram-negative sepsis. LPS can elicit a strong response from innate immune system and result in local or systemic adverse reactions. LPS can trigger massive inflam- matory responses and may result in immunopathology, for which the molecular basis is mediated by the signal path way of LPS. In recent years, a tremendous progress has been made in determining the associated proteins and recep tors in the LPS signaling that leads to the disease. This review gives a summary of recent progresses of research on LPS and LPS receptors.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2015年第4期910-913,共4页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(21372222)
关键词
脂多糖
脂多糖信号通路
脂多糖结合蛋白
脂多糖受体
lipopolysaccharide
lipopolysaccharide signal transduction
lipopolysaccharide-binding protein
lipopolysaccharide receptors
