期刊文献+

What are the effects of proton pump inhibitors on the small intestine? 被引量:9

What are the effects of proton pump inhibitors on the small intestine?
下载PDF
导出
摘要 Generally, proton-pump inhibitors(PPIs) have great benefit for patients with acid related disease with less frequently occurring side effects. According to a recent report, PPIs provoke dysbiosis of the small intestinal bacterial flora, exacerbating nonsteroidal anti-inflammatory drug-induced small intestinal injury.Several meta-analyses and systematic reviews have reported that patients treated with PPIs, as well as post-gastrectomy patients, have a higher frequency of small intestinal bacterial overgrowth(SIBO) compared to patients who lack the aforementioned conditions.Furthermore, there is insufficient evidence that these conditions induce Clostridium difficile infection. At this time, PPI-induced dysbiosis is considered a type of SIBO. It now seems likely that intestinal bacterial flora influence many diseases, such as inflammatory bowel disease, diabetes mellitus, obesity, nonalcoholic fatty liver disease, and autoimmune diseases.When attempting to control intestinal bacterial flora with probiotics, prebiotics, and fecal microbiota transplantation, etc., the influence of acid suppression therapy, especially PPIs, should not be overlooked. Generally, proton-pump inhibitors(PPIs) have great benefit for patients with acid related disease with less frequently occurring side effects. According to a recent report, PPIs provoke dysbiosis of the small intestinal bacterial flora, exacerbating nonsteroidal anti-inflammatory drug-induced small intestinal injury.Several meta-analyses and systematic reviews have reported that patients treated with PPIs, as well as post-gastrectomy patients, have a higher frequency of small intestinal bacterial overgrowth(SIBO) compared to patients who lack the aforementioned conditions.Furthermore, there is insufficient evidence that these conditions induce Clostridium difficile infection. At this time, PPI-induced dysbiosis is considered a type of SIBO. It now seems likely that intestinal bacterial flora influence many diseases, such as inflammatory bowel disease, diabetes mellitus, obesity, nonalcoholic fatty liver disease, and autoimmune diseases.When attempting to control intestinal bacterial flora with probiotics, prebiotics, and fecal microbiota transplantation, etc., the influence of acid suppression therapy, especially PPIs, should not be overlooked.
出处 《World Journal of Gastroenterology》 SCIE CAS 2015年第22期6817-6819,共3页 世界胃肠病学杂志(英文版)
关键词 Proton-pump inhibitors NONSTEROIDAL antiinflammatorydrug Small INTESTINE DYSBIOSIS Smallintestinal BACTERIAL OVERGROWTH Proton-pump inhibitors Nonsteroidal antiinflammatory drug Small intestine Dysbiosis Small intestinal bacterial overgrowth
  • 引文网络
  • 相关文献

参考文献21

  • 1Wallace JL, Syer S, Denou E, de Palma G, Vong L, McKnight W,Jury J, Bolla M, Bercik P, Collins SM, Verdu E, Ongini E. Protonpump inhibitors exacerbate NSAID-induced small intestinal injuryby inducing dysbiosis. Gastroenterology 2011; 141: 1314-1322,1322.e1-5 [PMID: 21745447 DOI: 10.1053/j.gastro.2011.06.075]. 被引量:1
  • 2Goldstein JL, Eisen GM, Lewis B, Gralnek IM, Zlotnick S, FortJG. Video capsule endoscopy to prospectively assess small bowelinjury with celecoxib, naproxen plus omeprazole, and placebo.Clin Gastroenterol Hepatol 2005; 3: 133-141 [PMID: 15704047]. 被引量:1
  • 3Fujimori S, Seo T, Gudis K, Ehara A, Kobayashi T, Mitsui K,Yonezawa M, Tanaka S, Tatsuguchi A, Sakamoto C. Prevention ofnonsteroidal anti-inflammatory drug-induced small-intestinal injuryby prostaglandin: a pilot randomized controlled trial evaluatedby capsule endoscopy. Gastrointest Endosc 2009; 69: 1339-1346[PMID: 19243767 DOI: 10.1016/j.gie.2008.08.017]. 被引量:1
  • 4Fujimori S, Takahashi Y, Seo T, Gudis K, Ehara A, KobayashiT, Mitsui K, Yonezawa M, Tanaka S, Tatsuguchi A, Sakamoto C.Prevention of traditional NSAID-induced small intestinal injury:recent preliminary studies using capsule endoscopy. Digestion2010; 82: 167-172 [PMID: 20588029 DOI: 10.1159/000308361]. 被引量:1
  • 5Lanas A, Ferrandez A. NSAID-induced gastrointestinal damage:current clinical management and recommendations for prevention.Chin J Dig Dis 2006; 7: 127-133 [PMID: 16808792]. 被引量:1
  • 6Bai K. On the mechanism of cereobiogen readjustment todysbiosis. Prog Clin Biol Res 1985; 181: 169-170 [PMID:3927307]. 被引量:1
  • 7Kanareykina SK, Misautova AA, Zlatkina AR, Levina EN.Proteus dysbioses in patients with ulcerative colitis. Nahrung 1987;31: 557-561 [PMID: 3657933]. 被引量:1
  • 8Knoke M, Bernhardt H. Clinical significance of changes of florain the upper digestive tract. Infection 1989; 17: 255-258 [PMID:2767770]. 被引量:1
  • 9Ruseler-van Embden JG, Schouten WR, van Lieshout LM.Pouchitis: result of microbial imbalance- Gut 1994; 35: 658-664[PMID: 8200561]. 被引量:1
  • 10Tamboli CP, Neut C, Desreumaux P, Colombel JF. Dysbiosis ininflammatory bowel disease. Gut 2004; 53: 1-4 [PMID: 14684564]. 被引量:1

同被引文献32

引证文献9

二级引证文献86

相关主题

;
使用帮助 返回顶部