摘要
目的评价自拟舒心活血汤治疗冠心病心绞痛的临床疗效。方法本研究为随机对照研究。将符合纳入标准的86例冠心病心绞痛患者按随机数字法分为2组各43例，对照组采用西医常规治疗，治疗组在对照组基础上加用自拟舒心活血汤治疗。采用循环酶法检测血清同型半胱氨酸（homocysteine，Hey），免疫比浊法测定高敏C反应蛋白（hypersensitive C-reactive protein, hs-CRP）；彩色多普勒超声诊断仪测定左心室射血分数（left ventricular ejection fraction, LVEF）、每搏输出量（strokevolume，sv）、心输出量（cardiacoutput．CO）、心脏指数（cardiacindex，CI），观察2组治疗前后各指标变化并评价其临床疗效。结果随访后4周，治疗组、对照组总有效率分别为90．7％（39／43）、74．4％（32／43），2组比较差异有统计学意义（X^2=3．957，P=0．047）。随访后4周，治疗组LVEF[（65．7±8．7）％比（61．5±8．4）％，t=2．277]、SV[（86．9±16．8）ml比（79．2±16．5）ml，t=2．144]、CO[（49.3±9．1）ml／m2比（44．7±8．8）ml／m2，t=2．3833、CI[（3．7±0．9）μmin·m^2比（3．3±0．7）L／min·m2，t=2．301]均较对照组明显升高泸〈0．05）。随访后4周，治疗组血清Hey[（8．7±3．7）μmol／L比（11．4±3．5）μmol／L，t=3．476]、hs-CRP[（2．7±1．1）mg／L比（3．5±1.3）mg／L，t=3．081]水平下降情况优于对照组（P〈O．01）。结论自拟舒心活血汤可改善冠心病心绞痛患者的心脏功能，提高临床疗效。
Objiective To investigate the clinical efficacy of Chinese medicine Shuxin-Huoxue decoction on coronary heart disease and angina pectoris. Methods This study was a randomized controlled trial. 86 patients with coronary heart disease and angina pectoris and conformed to the inclusive criteria were randomly divided into a control group and a treatment group, with 43 cases in each group. The control group was treated with conventional western medicine, the treatment group was treated with traditional Chinese medicine Shuxin-Huoxue decoction. Serum homocysteine （Hey） was measured by enzymatic cycling assay, high sensitive C reactive protein （hs-CRP） was measured by immunotubidimetric assay and left ventricular ejection fraction （LVEF）, stroke volume （SV）, cardiac output （CO）, cardiac index （CI） were measured by color doppler echocardiography before and after treatment. The clinical effect of the two groups was evaluated. Results The total effective rate of the treatment group and the control group was 90.7% （39/43） and 74.4% （32/43） respectively, there was significant difference （X^2=3.957,P=-0.047）. Followed up for 4 weeks, LVEF（65.7% ± 8.7% vs. 61.5% ± 8.4%, t=2.277）, SV（86.9 ：f 16.8 ml vs.79.2 ± 16.5 ml, t=2.144）, CO（49.3 ± 9.1 ml/m2 vs. 44.7 ± 8.8 ml/m2, t=2.383）, CI （3.7 ± 0.9 L/min·m2 vs. 3.3 ＋ 0.7 L/min·m2, t=2.301） of the treatment group were significantly improved after treatment than those of the control group （P〈0.05）, and the decrease of serum Hcy（8.7 ± 3.7 μmol/L vs. 11.4 ± 3.5 μmol/L, t=3.476）, hs-CRP （2.7 4- 1.1 mg/L vs. 3.5 ±1.3 mg/L, t=3.081） level of the treatment group were better than those of the control group（P〈0.01）. Conclusion Traditional Chinese medicine Shuxin-Huoxue decoction has good therapeutic effect on coronary heart disease and angina peetoris
出处
《国际中医中药杂志》
2015年第8期699-702,共4页
International Journal of Traditional Chinese Medicine
关键词
动脉硬化
心脏病
心绞痛
中草药
舒心活血汤
Arteriosclerosis
Heart diseases
Angina pectofis
Drugs, Chinese herbal
Shuxin-Huoxuedecoction
